Recent advances in the use of cell-penetrating peptides for medical and biological applications

SB Fonseca, MP Pereira, SO Kelley - Advanced drug delivery reviews, 2009 - Elsevier
The selective permeability of the plasma membrane prohibits most exogenous agents from
gaining cellular access. Since many therapeutics and reporter molecules must be …

Peptoids and polypeptoids at the frontier of supra-and macromolecular engineering

N Gangloff, J Ulbricht, T Lorson, H Schlaad… - Chemical …, 2016 - ACS Publications
In most general terms, polymers and their supramolecular assemblies have been defining
life on this planet since its conception. Polymers of nucleic acids carry the code of life and …

Structure–function relationships in peptoids: recent advances toward deciphering the structural requirements for biological function

SA Fowler, HE Blackwell - Organic & biomolecular chemistry, 2009 - pubs.rsc.org
Oligomers of N-substituted glycine, or peptoids, are versatile tools to probe biological
processes and hold promise as therapeutic agents. An underlying theme in the majority of …

[HTML][HTML] Synergistic chemopreventive effects of curcumin and berberine on human breast cancer cells through induction of apoptosis and autophagic cell death

K Wang, C Zhang, J Bao, X Jia, Y Liang, X Wang… - Scientific reports, 2016 - nature.com
Curcumin (CUR) and berberine (BBR) are renowned natural compounds that exhibit potent
anticancer activities through distinct molecular mechanisms. However, the anticancer …

Simultaneous modulation of COX‐2, p300, Akt, and Apaf‐1 signaling by melatonin to inhibit proliferation and induce apoptosis in breast cancer cells

J Wang, X Xiao, Y Zhang, D Shi, W Chen… - Journal of pineal …, 2012 - Wiley Online Library
Melatonin exhibits anti‐inflammatory and anticancer effects and could be a
chemopreventive and chemotherapeutic agent against cancers, but the precise mechanisms …

Polypeptoids: A perfect match for molecular definition and macromolecular engineering?

R Luxenhofer, C Fetsch… - Journal of Polymer …, 2013 - Wiley Online Library
Precision synthesis of polymers has been a hot topic in recent years. While this is
notoriously difficult to address for polymers with a C C backbone, Merrifield has discovered …

[HTML][HTML] Peptide-based polymer therapeutics

A Duro-Castano, I Conejos-Sánchez, MJ Vicent - Polymers, 2014 - mdpi.com
Polypeptides are envisaged to achieve a major impact on a number of different relevant
areas such as biomedicine and biotechnology. Acquired knowledge and the increasing …

[PDF][PDF] Polymer-drug conjugates: current status and future trends

F Greco, MJ Vicent - Front Biosci, 2008 - researchgate.net
From Ringsdorf's model to the clinic: current status of polymer-drug conjugates 2.1. Polymer
conjugates carrying orthodox anticancer agents 2.1. 1. Polymer-Dox conjugates 2.1. 2 …

[HTML][HTML] Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures

KN Mishra, BA Moftah, GA Alsbeih - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Radiation countermeasures are radioprotective agents that reduce the harmful effects of
ionizing radiation. They have wide range of applications extending from protection of normal …

Catechins protect against acrylamide-and glycidamide-induced cellular toxicity via rescuing cellular apoptosis and DNA damage

A Wang, X Chen, L Wang, W Jia, X Wan, J Jiao… - Food and Chemical …, 2022 - Elsevier
Acrylamide (AA) occurs in both various environmental and dietary sources and has raised
widespread concern as a probable carcinogen. Glycidamide (GA) is the main genotoxic …