Background: Contemporary studies suggest that familial hypercholesterolemia (FH) is more
frequent than previously reported and increasingly recognized as affecting individuals of all …

Lipids are insoluble in water and therefore cholesterol and triglycerides need to be
transported in association with proteins (ie, lipoproteins) in the bloodstream. Lipoproteins …

There is a need to identify high-risk features that predict early-onset atherosclerotic
cardiovascular disease (ASCVD). The authors provide insights to help clinicians identify and …

Familial hypercholesterolaemia is the most commonly encountered genetic condition that
predisposes individuals to premature cardiovascular disease. Nevertheless, most patients …

An elevated serum level of LDL cholesterol is a well-known risk factor for cardiovascular
disease (CVD), but the role of elevated triglyceride levels is debated. Controversies …

Background Cardiovascular disease (CVD) is the worldwide leading cause of morbidity and
mortality. An early risk detection of apparently healthy people before CVD onset has clinical …

Background and aims Management of familial hypercholesterolaemia (FH) may vary across
different settings due to factors related to population characteristics, practice, resources …

Background: A pathogenic variant in LDLR, APOB, or PCSK9 can be identified in 30% to
80% of patients with clinically-diagnosed familial hypercholesterolemia (FH). Alternatively,∼ …

Familial hypercholesterolaemia is a common inherited disorder characterized by abnormally
elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time …

Background: Genetic screening programs in unselected individuals with increased levels of
low-density lipoprotein cholesterol (LDL-C) have shown modest results in identifying …