Over 500 natural and synthetic amino acids have been genetically encoded in the last two
decades. Incorporating these noncanonical amino acids into proteins enables many …

Innate immunity is essential for the host against pathogens, cancer, and autoimmunity. The
innate immune system encodes many sensor, adaptor, and effector proteins and relies on …

Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor
that produced IFN-I and regulated innate immune response, subsequent studies have …

Mitochondrial antiviral signaling protein (MAVS) is an adapter that recruits and activates
IRF3. However, the mechanisms underpinning the interplay between MAVS and IRF3 are …

Abstract Interferon Regulatory Factors (IRFs), a family of transcription factors, profoundly
influence the immune system, impacting both physiological and pathological processes …

Post‐translational modifications (PTMs) of proteins not only exponentially increase the
diversity of proteoforms, but also contribute to dynamically modulating the localization …

An emerging set of results suggests that liquid-liquid phase separation (LLPS) is the basis
for the formation of membrane-less compartments in cells. Evidence is now mounting that …

Biomolecular condensates regulate transcription by dynamically compartmentalizing the
transcription machinery. Classic models of transcription regulation focus on the recruitment …

Biomolecular condensates or membraneless organelles (MLOs) formed by liquid-liquid
phase separation (LLPS) divide intracellular spaces into discrete compartments for specific …

SARS-CoV-2 has been a pandemic threat to human health and the worldwide economy, but
efficient treatments are still lacking. Type I and III interferons are essential for controlling viral …