Interleukin‐31: The “itchy” cytokine in inflammation and therapy
The cytokine interleukin‐31 has been implicated in the pathophysiology of multiple atopic
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
disorders such as atopic dermatitis (AD), allergic rhinitis, and airway hyper‐reactivity. In AD …
Spotlight on microRNAs in allergy and asthma
In past 10 years, microRNAs (miRNAs) have gained scientific attention due to their
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …
importance in the pathophysiology of allergic diseases and their potential as biomarkers in …
Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis
JI Silverberg, E Guttman-Yassky, D Thaçi… - … England Journal of …, 2023 - Mass Medical Soc
Background Lebrikizumab, a high-affinity IgG4 monoclonal antibody targeting interleukin-13,
prevents the formation of the interleukin-4Rα–interleukin-13Rα1 heterodimer receptor …
prevents the formation of the interleukin-4Rα–interleukin-13Rα1 heterodimer receptor …
Efficacy and safety of upadacitinib in patients with moderate to severe atopic dermatitis: analysis of follow-up data from the measure up 1 and measure up 2 …
Importance Primary results from the Measure Up 1 and Measure Up 2 studies demonstrated
upadacitinib efficacy and safety through 16 weeks in patients with atopic dermatitis. Longer …
upadacitinib efficacy and safety through 16 weeks in patients with atopic dermatitis. Longer …
Efficacy and safety of lebrikizumab, a high-affinity interleukin 13 inhibitor, in adults with moderate to severe atopic dermatitis: a phase 2b randomized clinical trial
Importance Interleukin 13 (IL-13) is a central pathogenic mediator driving multiple features of
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …
atopic dermatitis (AD) pathophysiology. Objective To evaluate the efficacy and safety of …
[HTML][HTML] Neuroimmune communication regulating pruritus in atopic dermatitis
Atopic dermatitis (AD) is a common, chronic-relapsing inflammatory skin disease with
significant disease burden. Genetic and environmental trigger factors contribute to AD …
significant disease burden. Genetic and environmental trigger factors contribute to AD …
Efficacy and safety of lebrikizumab in combination with topical corticosteroids in adolescents and adults with moderate-to-severe atopic dermatitis: a randomized …
EL Simpson, M Gooderham, A Wollenberg… - JAMA …, 2023 - jamanetwork.com
Importance Lebrikizumab (LEB), a high-affinity monoclonal antibody targeting interleukin (IL)-
13, demonstrated efficacy and safety in patients with moderate-to-severe atopic dermatitis …
13, demonstrated efficacy and safety in patients with moderate-to-severe atopic dermatitis …
Single-cell transcriptomics combined with interstitial fluid proteomics defines cell type–specific immune regulation in atopic dermatitis
TB Rojahn, V Vorstandlechner, T Krausgruber… - Journal of Allergy and …, 2020 - Elsevier
Background Atopic dermatitis (AD) is the most common chronic inflammatory skin disease,
but its complex pathogenesis is only insufficiently understood, resulting in still limited …
but its complex pathogenesis is only insufficiently understood, resulting in still limited …
Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options
T Bieber, AS Paller, K Kabashima… - Journal of the …, 2022 - Wiley Online Library
Atopic dermatitis (AD) is a chronic, heterogenous, inflammatory skin disorder associated
with a high skin‐related health burden, typically starting in childhood and often persisting …
with a high skin‐related health burden, typically starting in childhood and often persisting …
Th2 modulation of transient receptor potential channels: an unmet therapeutic intervention for atopic dermatitis
J Meng, Y Li, MJM Fischer, M Steinhoff… - Frontiers in …, 2021 - frontiersin.org
Atopic dermatitis (AD) is a multifaceted, chronic relapsing inflammatory skin disease that
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …
affects people of all ages. It is characterized by chronic eczema, constant pruritus, and …