[HTML][HTML] The influence of higher-order epistasis on biological fitness landscape topography
DM Weinreich, Y Lan, J Jaffe… - Journal of statistical …, 2018 - Springer
The effect of a mutation on the organism often depends on what other mutations are already
present in its genome. Geneticists refer to such mutational interactions as epistasis. Pairwise …
present in its genome. Geneticists refer to such mutational interactions as epistasis. Pairwise …
[HTML][HTML] The Alzheimer's disease–protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool
SS Siddiqui, SA Springer, A Verhagen… - Journal of Biological …, 2017 - ASBMB
The immunomodulatory receptor Siglec-3/CD33 influences risk for late-onset Alzheimer's
disease (LOAD), an apparently human-specific post-reproductive disease. CD33 generates …
disease (LOAD), an apparently human-specific post-reproductive disease. CD33 generates …