Cryptococcus: from environmental saprophyte to global pathogen

RC May, NRH Stone, DL Wiesner, T Bicanic… - Nature Reviews …, 2016 - nature.com
Cryptococcosis is a globally distributed invasive fungal infection that is caused by species
within the genus Cryptococcus which presents substantial therapeutic challenges. Although …

A holistic review on Cryptococcus neoformans

SS Rathore, J Sathiyamoorthy, C Lalitha… - Microbial …, 2022 - Elsevier
Cryptococcus neoformans is an encapsulated fungal pathogen that causes infection in
immunocompromised individuals such as HIV patients, organ transplant patients …

Fungal strategies to evade the host immune recognition

MJ Hernández-Chávez, LA Pérez-García… - Journal of Fungi, 2017 - mdpi.com
The recognition of fungal cells by the host immune system is key during the establishment of
a protective anti-fungal response. Even though the immune system has evolved a vast …

Cryptococcus neoformans urease affects the outcome of intracellular pathogenesis by modulating phagolysosomal pH

MS Fu, C Coelho, CM De Leon-Rodriguez… - PLoS …, 2018 - journals.plos.org
Cryptococcus neoformans is a facultative intracellular pathogen and its interaction with
macrophages is a key event determining the outcome of infection. Urease is a major …

Cryptococcal pathogenic mechanisms: a dangerous trip from the environment to the brain

SK Esher, O Zaragoza, JA Alspaugh - Memorias do Instituto Oswaldo …, 2018 - SciELO Brasil
Cryptococcus neoformans is an opportunistic pathogenic yeast that causes serious
infections, most commonly of the central nervous system (CNS). C. neoformans is mainly …

Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy

ML Korir, RS Doster, J Lu, MA Guevara… - Nature …, 2022 - nature.com
Perinatal infection with Streptococcus agalactiae, or Group B Streptococcus (GBS), is
associated with preterm birth, neonatal sepsis, and stillbirth. Here, we study the interactions …

Cryptococcus and Phagocytes: Complex Interactions that Influence Disease Outcome

CM Leopold Wager, CR Hole, KL Wozniak… - Frontiers in …, 2016 - frontiersin.org
Cryptococcus neoformans and C. gattii are fungal pathogens that cause life-threatening
disease. These fungi commonly enter their host via inhalation into the lungs where they …

Mechanisms of Cryptococcus neoformans-Mediated Host Damage

A Casadevall, C Coelho, A Alanio - Frontiers in immunology, 2018 - frontiersin.org
Cryptococcus neoformans is not usually considered a cytotoxic fungal pathogen but there is
considerable evidence that this microbe can damage host cells and tissues. In this essay …

Fungal mechanisms of intracellular survival: what can we learn from bacterial pathogens?

PV Stuckey, FH Santiago-Tirado - Infection and Immunity, 2023 - Am Soc Microbiol
Fungal infections represent a major, albeit neglected, public health threat with serious
medical and economic burdens globally. With unacceptably high mortality rates, invasive …

Internalized Cryptococcus neoformans activates the canonical caspase-1 and the noncanonical caspase-8 inflammasomes

M Chen, Y Xing, A Lu, W Fang, B Sun… - The Journal of …, 2015 - journals.aai.org
Cryptococcus neoformans is an opportunistic fungal pathogen that causes cryptococccosis
in immunocompromised patients as well as immunocompetent individuals. Host cell surface …