Natural withanolides, an update
G Xia, S Cao, L Chen, F Qiu - Natural Product Reports, 2022 - pubs.rsc.org
Covering: March 2010 to December 2020. Previous review: Nat. Prod. Rep., 2011, 28, 705
This review summarizes the latest progress and perspectives on the structural classification …
This review summarizes the latest progress and perspectives on the structural classification …
[HTML][HTML] Ethnobotanical uses and phytochemical, biological, and toxicological profiles of Datura metel L.: a review
Datura metel L., a recognized poisonous plant in the Solanaceae family, is widely distributed
in the world. Traditionally, D. metel is used in many diseases, including neurological and …
in the world. Traditionally, D. metel is used in many diseases, including neurological and …
The genus Datura L.(Solanaceae): a systematic review of botany, traditional use, phytochemistry, pharmacology, and toxicology
W Lian, Y Wang, J Zhang, Y Yan, C Xia, H Gan… - Phytochemistry, 2022 - Elsevier
The genus Datura has been used as an important traditional medicine in China, as well as
in other countries worldwide. This review summarizes the latest progress and perspective of …
in other countries worldwide. This review summarizes the latest progress and perspective of …
The critical role of the phytosterols in modulating tumor microenvironment via multiple signaling: A comprehensive molecular approach
Cancer is the leading cause of mortality and morbidity worldwide, and its cases are rapidly
increasing every year. Several factors contribute to the development of tumorigenesis …
increasing every year. Several factors contribute to the development of tumorigenesis …
Molecular targets and mechanisms of anti-cancer effects of withanolides
Z Zhang, Y Yang, Y Xu, Y Liu, H Li, L Chen - Chemico-Biological …, 2023 - Elsevier
Withanolides are a class of natural products with a steroidal lactone structure that exhibit a
broad spectrum of anti-cancer effects. To date, several studies have shown that their …
broad spectrum of anti-cancer effects. To date, several studies have shown that their …
[HTML][HTML] Toxicity evaluation induced by single and 28-days repeated exposure of withametelin and daturaolone in Sprague Dawley rats
Safe preclinical dose determination is predictive of human toxicity and can have a profound
impact on the overall progress of the compound in early drug discovery process. In this …
impact on the overall progress of the compound in early drug discovery process. In this …
Coagulansin-A improves spatial memory in 5xFAD Tg mice by targeting Nrf-2/NF-κB and Bcl-2 pathway
The present study was designed to investigate the underlying molecular signaling of
Coagulansin-A (Coag-A) as a therapeutic agent against Alzheimer's disease (AD) …
Coagulansin-A (Coag-A) as a therapeutic agent against Alzheimer's disease (AD) …
[HTML][HTML] Anticancer mechanisms of bioactive compounds from Solanaceae: An update
DO Nkwe, B Lotshwao, G Rantong, J Matshwele… - Cancers, 2021 - mdpi.com
Simple Summary The Solanaceae plant family has been a good source of natural
compounds that can treat several diseases, including cancer. However, the site and …
compounds that can treat several diseases, including cancer. However, the site and …
[HTML][HTML] Oxidative stress and AKT-associated angiogenesis in a zebrafish model and its potential application for withanolides
Oxidative stress and the AKT serine/threonine kinase (AKT) signaling pathway are essential
regulators in cellular migration, metastasis, and angiogenesis. More than 300 withanolides …
regulators in cellular migration, metastasis, and angiogenesis. More than 300 withanolides …
[HTML][HTML] Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Metabolic alterations in cancer precipitate in associated dependencies that can be
therapeutically exploited. To meet this goal, natural product-inspired small molecules can …
therapeutically exploited. To meet this goal, natural product-inspired small molecules can …