One essential prokaryotic cell function is the transport of proteins from the cytoplasm into
other compartments of the cell, the environment, and/or other bacteria or eukaryotic cells—a …

Bacteria have evolved a remarkable array of sophisticated nanomachines to export various
virulence factors across the bacterial cell envelope. In recent years, considerable progress …

Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …

Neutrophils represent the main infected cell population in the lungs of active tuberculosis
patients. Efficient removal of infected and dying neutrophils is required to protect the …

We have an enormous number of commensal bacteria in our intestine, moreover, the foods
that we ingest and the water we drink is sometimes contaminated with pathogenic …

Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …

Mycobacterium tuberculosis (Mtb) uses efficient strategies to evade the eradication by
professional phagocytes, involving—as recently confirmed—escape from phagosomal …

Mycobacteria possess different type VII secretion (T7S) systems to secrete proteins across
their unusual cell envelope. One of these systems, ESX-5, is only present in slow-growing …

Bacterial nutrition is an essential aspect of host–pathogen interaction. For the intracellular
pathogen Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis in humans …

Iron is essential for nearly all bacterial pathogens, including Mycobacterium tuberculosis
(Mtb), but is severely limited in the human host. To meet its iron needs, Mtb secretes …