Mitochondrial transfer/transplantation: an emerging therapeutic approach for multiple diseases

Z Liu, Y Sun, Z Qi, L Cao, S Ding - Cell & bioscience, 2022 - Springer
Mitochondria play a pivotal role in energy generation and cellular physiological processes.
These organelles are highly dynamic, constantly changing their morphology, cellular …

Mitochondria-derived cell-to-cell communication

ZAA Dache, AR Thierry - Cell Reports, 2023 - cell.com
In addition to their intracellular mobility, mitochondria and their components can exist
outside the cells from which they originate. As a result, they are capable of acting on non …

[HTML][HTML] Mitochondria in ischemic stroke: new insight and implications

F Liu, J Lu, A Manaenko, J Tang, Q Hu - Aging and disease, 2018 - ncbi.nlm.nih.gov
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial
dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) …

Renal damage induced by cadmium and its possible therapy by mitochondrial transplantation

EY Hernández-Cruz, I Amador-Martínez… - Chemico-biological …, 2022 - Elsevier
Cadmium (Cd) is one of the most toxic metals without biological function, and its
accumulation in living organisms has been reported. The kidney is a target organ in Cd …

Mitochondrial transfer in cancer: a comprehensive review

LX Zampieri, C Silva-Almeida, JD Rondeau… - International journal of …, 2021 - mdpi.com
Depending on their tissue of origin, genetic and epigenetic marks and microenvironmental
influences, cancer cells cover a broad range of metabolic activities that fluctuate over time …

Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer

JC Chang, HS Chang, YC Wu, WL Cheng… - Journal of Experimental …, 2019 - Springer
Background The transfer of whole mitochondria that occurs during cell contact has been
found to support cancer progression. However, the regulatory role of mitochondria alone is …

Mitochondrial transplantation: from animal models to clinical use in humans

JD McCully, DB Cowan, SM Emani, PJ Del Nido - Mitochondrion, 2017 - Elsevier
Mitochondrial transplantation is a novel therapeutic intervention to treat
ischemia/reperfusion related disorders. The method for mitochondrial transplantation is …

Mitochondrial transplantation for therapeutic use

JD McCully, S Levitsky, PJ Del Nido… - Clinical and translational …, 2016 - Springer
Mitochondria play a key role in the homeostasis of the vast majority of the body's cells. In the
myocardium where mitochondria constitute 30% of the total myocardial cell volume …

Effects of mitochondrial transplantation on bioenergetics, cellular incorporation, and functional recovery after spinal cord injury

JL Gollihue, SP Patel, KC Eldahan, DH Cox… - Journal of …, 2018 - liebertpub.com
Our previous studies reported that pharmacological maintenance of mitochondrial
bioenergetics after experimental spinal cord injury (SCI) provided functional …

Allogeneic/xenogeneic transplantation of peptide-labeled mitochondria in Parkinson's disease: restoration of mitochondria functions and attenuation of 6 …

JC Chang, SL Wu, KH Liu, YH Chen, CS Chuang… - Translational …, 2016 - Elsevier
Although restoration of mitochondrial function in mitochondrial diseases through peptide-
mediated allogeneic mitochondrial delivery (PMD) has been demonstrated in vitro, the in …