Despite their ubiquitous presence, placebos and placebo effects retain an ambiguous and
unsettling presence in biomedicine. Specifically focused on chronic pain, this review …

Context Despite increasing awareness about the potential impact of financial conflicts of
interest on biomedical research, no comprehensive synthesis of the body of evidence …

Summary Background The RTS, S/AS01 malaria vaccine targets the circumsporozoite
protein, inducing antibodies associated with the prevention of Plasmodium falciparum …

Across the last forty years, epidemiology has developed into a vibrant scientific discipline
that brings together the social and biological sciences, incorporating everything from …

Many believe that informed consent makes clinical research ethical. However, informed
consent is neither necessary nor sufficient for ethical clinical research. Drawing on the basic …

ContextIntense debate persists about the need for placebo-controlled groups in clinical trials
of medications for major depressive disorder (MDD). There is continuing interest in the …

The World Medical Association's Declaration of Helsinki was first adopted in 1964. In its 40‐
year lifetime the Declaration has been revised five times and has risen to a position of …

Research with human subjects 1 exemplifies the perennial conflict between the good of the
individual and the good of society. Policies and procedures that protect the rights and …

Placebo‐controlled trials are the ideal for evaluating medical treatment efficacy. They allow
for control of the placebo effect and are most efficient, requiring the smallest numbers of …

The recent introduction of covert administration of treatment to biomedical research has
produced some interesting results, with many clinical and ethical implications. Concealed …