Adult hippocampal neurogenesis in major depressive disorder and Alzheimer's disease

T Berger, H Lee, AH Young, D Aarsland… - Trends in molecular …, 2020 - cell.com
Depression and dementia are major public health problems. Major depressive disorder
(MDD) and Alzheimer's disease (AD) reciprocally elevate the risk for one another. No …

Methods to study adult hippocampal neurogenesis in humans and across the phylogeny

J Terreros‐Roncal, M Flor‐García… - …, 2023 - Wiley Online Library
The hippocampus hosts the continuous addition of new neurons throughout life—a
phenomenon named adult hippocampal neurogenesis (AHN). Here we revisit the …

Activation of hypothalamic-enhanced adult-born neurons restores cognitive and affective function in Alzheimer's disease

YD Li, YJ Luo, L Xie, DS Tart, RN Sheehy, L Zhang… - Cell stem cell, 2023 - cell.com
Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …

Depression in dementia with Lewy bodies: a critical update

KA Jellinger - Journal of Neural Transmission, 2023 - Springer
Depression with an estimated prevalence of 35% is a frequent manifestation of dementia
with Lewy bodies (DLB), having negative effects on cognitive performance and life …

The impact of adult neurogenesis on affective functions: of mice and men

M Alonso, AC Petit, PM Lledo - Molecular Psychiatry, 2024 - nature.com
In most mammals, new neurons are not only produced during embryogenesis but also after
birth. Soon after adult neurogenesis was discovered, the influence of recruiting new neurons …

Adult human hippocampal neurogenesis: controversy and evidence

H Lee, S Thuret - Trends in molecular medicine, 2018 - cell.com
The hippocampus has been described as one of the few sites in the mammalian brain
capable of generating new cells continuously throughout life. Two recent studies that report …

REM sleep behavior disorder (RBD) in dementia with Lewy bodies (DLB)

PC Chan, HH Lee, CT Hong, CJ Hu… - Behavioural …, 2018 - Wiley Online Library
Rapid eye movement sleep behavior disorder (RBD) is a parasomnia, with abnormal dream‐
enacting behavior during the rapid eye movement (REM) sleep. RBD is either idiopathic or …

The therapeutic potential of traditional Chinese medicine in depression: targeting adult hippocampal neurogenesis

L Feng, H Xing, K Zhang - Phytomedicine, 2022 - Elsevier
Background Depression is a common mental disorder characterized by persistent sadness
and lack of interest or pleasure in previously rewarding or enjoyable activities …

Hippocampal neurogenesis in adult primates: a systematic review

T Elliott, KY Liu, J Hazan, J Wilson, H Vallipuram… - Molecular …, 2024 - nature.com
It had long been considered that no new neurons are generated in the primate brain beyond
birth, but recent studies have indicated that neurogenesis persists in various locations …

Expression of neurogenic markers in Alzheimer's disease: a systematic review and metatranscriptional analysis

A Gatt, H Lee, G Williams, S Thuret, C Ballard - Neurobiology of Aging, 2019 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia characterized by substantial
neuronal loss and progressive brain atrophy. Animal studies have suggested that the …