The benzophenone scaffold represents a ubiquitous structure in medicinal chemistry
because it is found in several naturally occurring molecules which exhibit a variety of …

Pyridine, a compound with a heterocyclic structure, is a key player in medicinal chemistry
and drug design. It is widely used as a framework for the design of biologically active …

A series of potential biological active substituted thiadiazoles 5a-j and oxadiazoles 6a-j were
obtained via a multistep synthesis sequence with a simple and convenient approach by …

A great extent of nitrogen containing heterocyclic moiety comprising sulfur atom is
recognized as a valuable combination of therapeutics in medicinal chemistry. In particular …

Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-
1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its …

Novel analogs of quinoline and isoindoline containing various heterocycles, such as
tetrazole, triazole, pyrazole, and pyridine, were synthesized and characterized using FT-IR …

Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …

Increasing evidence shows that, in addition to the classical function of protein processing
and transport, the Golgi apparatus (GA) is also involved in apoptosis, one of the most …

Mouse models are irreplaceable tools for the study of carcinogenesis and the availability of
rodent models have enabled rational screening of drugs. Hematological malignancies have …

Pyridine derivatives with different heterocyclic nucleus have shown potent pharmacological
properties as a part from the previously marketed drugs. The title compound, ethyl 2-[5-nitro …