Head and neck squamous cell carcinoma (HNSCC) is currently one of the 10 most common
malignancies worldwide, characterized by a biologically highly diverse group of tumors with …

Cancer incidence and mortality, metastasis, drug resistance and recurrence are still the
critical issues of oncological diseases. In this scenario, increasing scientific evidences …

Malignant melanoma is a tumor characterized by a very high level of heterogeneity,
responsible for its malignant behavior and ability to escape from standard therapies. In this …

The CD133 cell membrane glycoprotein, also termed prominin-1, is expressed on some of
the tumor cells of both solid and blood malignancies. The CD133-positive tumor cells were …

Melanoma, which is an aggressive skin cancer, is currently the fifth and seventh most
common cancer in men and women, respectively. The American Cancer Society reported …

Recently, it has been described that programmed cell death protein 1 (PD-1) overexpressing
melanoma cells are highly aggressive. However, until now it has not been defined which …

Melanoma frequently harbors genetic alterations in key molecules leading to the aberrant
activation of PI3K and its downstream pathways. Although the role of PI3K/AKT/mTOR in …

Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological
features such as cancer progression in all cancer types. By using melanospheres …

Simple Summary Melanoma is the third most common type of skin cancer. Melanoma is a
heterogeneous tumor, composed of genetically divergent subpopulations. These …

The worldwide incidence of malignant melanoma is steadily increasing, suggesting a
probable melanoma “epidemic.” From a clinical point of view, malignant melanoma still is an …