Chromatin has distinct three-dimensional (3D) architectures important in key biological
processes, such as cell cycle, replication, differentiation, and transcription regulation. In turn …

Simple Summary Loss of SMARCB1 has been identified as the sole mutation in a number of
rare pediatric and adult cancers, most of which have a poor prognosis despite intensive …

ATP-dependent chromatin remodeling SWI/SNF complexes exist in three subcomplexes:
canonical BAF (cBAF), polybromo BAF (PBAF), and a newly described non-canonical BAF …

Abstract Bromodomain-containing protein 9 (BRD9), a component of non-canonical BAF
chromatin remodeling complex, has been identified as a critical therapeutic target in …

The c-Myc signaling is a new emerging target in cancer therapy. Activation of c-Myc
signaling leads to cancer growth and invasion in vitro and in vivo. The stability of c-Myc can …

Abstract Bromodomain-containing protein 9 (BRD9) is a specific subunit of the non-
canonical SWI/SNF (ncBAF) chromatin-remodeling complex, whose function in human …

Bromodomain-containing proteins are readers of acetylated lysine and play important roles
in cancer. Bromodomain-containing protein 7 (BRD7) is implicated in multiple malignancies; …

Macrophages induce a number of inflammatory response genes in response to stimulation
with microbial ligands. In response to endotoxin Lipid A, a gene-activation cascade of …

Chronic inflammation is one of the definite factors leading to the occurrence and
development of tumors, including prostate cancer (PCa). The androgen receptor (AR) …

Proteolysis-targeting chimeras (PROTACs) are heterobifunctional small molecules that
induce the ternary complex formation between a protein-of-interest (POI) and an E3 ligase …