Nick Induced Dynamics in Supercoiled DNA Facilitates the Protein Target Search Process

Sangeeta, A Bhattacherjee - The Journal of Physical Chemistry B, 2024 - ACS Publications
A DNA nick, defined as a discontinuity in a double-stranded DNA molecule where the
phosphodiester bond between adjacent nucleotides of one strand is absent due to enzyme …

Insights into the behaviour of phosphorylated DNA breaks from molecular dynamic simulations

L Zhang, O Lampela, LL Lehtiö, AH Juffer - Computational Biology and …, 2024 - Elsevier
Single-stranded breaks (SSBs) are the most frequent DNA lesions threatening genomic
integrity-understanding how DNA sensor proteins recognize certain SSB types is crucial for …