Abstract Treatment of acute lung injury (ALI) and its most severe form, acute respiratory
distress syndrome (ARDS), remain unsolved problems of intensive care medicine …

The acute respiratory distress syndrome (ARDS) is a life-threatening lung condition resulting
from direct and indirect insults to the lung. It is characterized by disruption of the endothelial …

Acute lung injury is a complex clinical syndrome involving acute inflammation, microvascular
damage, and increased pulmonary vascular and epithelial permeability, frequently resulting …

Lung disorders such as asthma, acute respiratory distress syndrome (ARDS), chronic
obstructive lung disease (COPD), and interstitial lung disease (ILD) show a few common …

Autoantibodies (AABs) play a critical role in the pathogenesis of autoimmune diseases
(AIDs) and serve as a diagnostic and prognostic tool in assessing these complex disorders …

Previous observations made by our laboratory indicate that Bruton's tyrosine kinase (Btk)
may play an important role in the pathophysiology of local inflammation in acute lung injury …

Autoantibodies to cytokines are increasingly being detected in association with
immunodeficient, autoimmune and immune dysregulated states. Presence of these …

ALI/ARDS (acute lung injury/acute respiratory distress syndrome) is a severe inflammatory
lung disease associated with very high mortality. Importantly, no effective therapy has been …

Previous observations by our laboratory indicate that the presence of anti–IL-8 autoantibody:
IL-8 immune complexes in lung fluids from patients with acute lung injury/acute respiratory …

Our previous studies demonstrated that a significant fraction of interleukin-8 (IL-8) in lung
fluids from patients with acute lung injury (ALI) and the acute respiratory distress syndrome …