Mechanisms of antisense transcription initiation with implications in gene expression, genomic integrity and disease pathogenesis

P Barman, D Reddy, SR Bhaumik - Non-coding RNA, 2019 - mdpi.com
Non-coding antisense transcripts arise from the strand opposite the sense strand. Over 70%
of the human genome generates non-coding antisense transcripts while less than 2% of the …

ASF1A and ATM regulate H3K56-mediated cell-cycle checkpoint recovery in response to UV irradiation

A Battu, A Ray, AA Wani - Nucleic acids research, 2011 - academic.oup.com
Successful DNA repair within chromatin requires coordinated interplay of histone
modifications, chaperones and remodelers for allowing access of repair and checkpoint …

Nuclear Hat1p complex (NuB4) components participate in DNA repair-linked chromatin reassembly

Z Ge, H Wang, MR Parthun - Journal of Biological Chemistry, 2011 - ASBMB
Chromatin is disassembled and reassembled during DNA repair. To assay chromatin
reassembly accompanying DNA double strand break repair, ChIP analysis can be used to …

Fine-tuning of FACT by the ubiquitin proteasome system in regulation of transcriptional elongation

R Sen, J Ferdoush, A Kaja… - Molecular and cellular …, 2016 - Taylor & Francis
FACT (fa cilitates c hromatin t ranscription), an evolutionarily conserved histone chaperone
involved in transcription and other DNA transactions, is upregulated in cancers, and its …

Deacetylation of H4 lysine16 affects acetylation of lysine residues in histone H3 and H4 and promotes transcription of constitutive genes

A Ray, P Khan, R Nag Chaudhuri - Epigenetics, 2021 - Taylor & Francis
Histone modification map of H4 N-terminal tail residues in Saccharomyces cerevisiae
reveals the prominence of lysine acetylation. Previous reports have indicated the importance …

An mRNA capping enzyme targets FACT to the active gene to enhance the engagement of RNA polymerase II into transcriptional elongation

R Sen, A Kaja, J Ferdoush, S Lahudkar… - … and Cellular Biology, 2017 - Taylor & Francis
We have recently demonstrated that an mRNA capping enzyme, Cet1, impairs promoter-
proximal accumulation/pausing of RNA polymerase II (Pol II) independently of its capping …

RNA Polymerase II Dependent Crosstalk between H4K16 Deacetylation and H3K56 Acetylation Promotes Transcription of Constitutively Expressed Genes

P Khan, P Singha, R Nag Chaudhuri - Molecular and Cellular …, 2023 - Taylor & Francis
Nucleosome dynamics in the coding region of a transcriptionally active locus is critical for
understanding how RNA polymerase II progresses through the gene body. Histone …

Eaf1p is required for recruitment of NuA4 in targeting TFIID to the promoters of the ribosomal protein genes for transcriptional initiation in vivo

B Uprety, R Sen, SR Bhaumik - Molecular and Cellular Biology, 2015 - Am Soc Microbiol
NuA4 (nucleosome acetyltransferase of H4) promotes transcriptional initiation of TFIID (a
complex of TBP and TBP-associated factors [TAFs])-dependent ribosomal protein genes …

Acetylation of H3K56 orchestrates UV-responsive chromatin events that generate DNA accessibility during Nucleotide Excision Repair

P Khan, RN Chaudhuri - DNA repair, 2022 - Elsevier
Histone modifications have long been related to DNA damage response. Nucleotide
excision repair pathway that removes helix-distorting lesions necessitates DNA accessibility …

Rad26p regulates the occupancy of histone H2A–H2B dimer at the active genes in vivo

S Malik, P Chaurasia, S Lahudkar… - Nucleic Acids …, 2012 - academic.oup.com
Recently, we have demonstrated a predominant association of Rad26p with the coding
sequences but not promoters of several GAL genes following transcriptional induction. Here …