Acute respiratory distress syndrome (ARDS) is a heterogeneous syndrome, presenting
challenges to both frontline clinicians and researchers testing novel therapies. Identifying …

Despite progress in the supportive care available for critically ill patients, few advances have
been made in the search for effective disease-modifying therapeutic options. The fact that …

The aim of these guidelines is to update the 2017 clinical practice guideline (CPG) of the
European Society of Intensive Care Medicine (ESICM). The scope of this CPG is limited to …

Background: Since publication of the 2012 Berlin definition of acute respiratory distress
syndrome (ARDS), several developments have supported the need for an expansion of the …

Rationale: If the risk of ventilator-induced lung injury in acute respiratory distress syndrome
(ARDS) is causally determined by driving pressure rather than by Vt, then the effect of …

Background The benefits of early continuous neuromuscular blockade in patients with acute
respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain …

Background Individualized positive end-expiratory pressure (PEEP) by electrical impedance
tomography (EIT) has potential interest in the optimization of ventilation distribution in acute …

Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence
of numerous new avenues of exciting mitochondria-related research including …

Importance Although vaccination substantially reduces the risk of severe COVID-19, it is yet
unknown whether vaccinated patients who develop COVID-19 and require invasive …

Purpose Acute respiratory distress syndrome (ARDS) is a serious respiratory condition with
high mortality and associated morbidity. The objective of this study is to develop and …