Nonischemic dilated cardiomyopathy (DCM) often has a genetic pathogenesis. Because of
the large number of genes and alleles attributed to DCM, comprehensive genetic testing …

Variants in> 12 genes encoding sarcomeric proteins can cause various cardiomyopathies.
The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy …

Cardiometabolic diseases are the leading cause of death worldwide. Despite a known
genetic component, our understanding of these diseases remains incomplete. Here, we …

Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and
contractile dysfunction. Genetic mutations involving genes that encode cytoskeletal …

Given the global burden of heart failure, strategies to understand the underlying cause or to
provide prognostic information are critical to reducing the morbidity and mortality associated …

Over the last quarter-century, there has been tremendous progress in genetics research that
has defined molecular causes for cardiomyopathies. More than a thousand mutations have …

Background Dilated cardiomyopathy and hypertrophic cardiomyopathy arise from mutations
in many genes. TTN, the gene encoding the sarcomere protein titin, has been insufficiently …

Genomic sequencing provides many opportunities in newborn clinical care, but the
challenges of interpreting and reporting newborn genomic sequencing (nGS) results need to …

The recent discovery of heterozygous human mutations that truncate full-length titin (TTN, an
abundant structural, sensory, and signaling filament in muscle) as a common cause of end …

Human mutations that truncate the massive sarcomere protein titin [TTN-truncating variants
(TTNtvs)] are the most common genetic cause for dilated cardiomyopathy (DCM), a major …