Haematopoietic stem cell activity and interactions with the niche
S Pinho, PS Frenette - Nature reviews Molecular cell biology, 2019 - nature.com
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …
Nerves in cancer
AH Zahalka, PS Frenette - Nature Reviews Cancer, 2020 - nature.com
The contribution of nerves to the pathogenesis of malignancies has emerged as an
important component of the tumour microenvironment. Recent studies have shown that …
important component of the tumour microenvironment. Recent studies have shown that …
The bone marrow microenvironment at single-cell resolution
The bone marrow microenvironment has a key role in regulating haematopoiesis, but its
molecular complexity and response to stress are incompletely understood. Here we map the …
molecular complexity and response to stress are incompletely understood. Here we map the …
[HTML][HTML] Niches that regulate stem cells and hematopoiesis in adult bone marrow
S Comazzetto, B Shen, SJ Morrison - Developmental cell, 2021 - cell.com
In mammals, hematopoietic stem cells (HSCs) engage in hematopoiesis throughout adult
life within the bone marrow, where they produce the mature cells necessary to maintain …
life within the bone marrow, where they produce the mature cells necessary to maintain …
Adult haematopoietic stem cell niches
Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …
cells and regulate their function. Recent advances have improved our understanding of the …
Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF
BO Zhou, H Yu, R Yue, Z Zhao, JJ Rios, O Naveiras… - Nature cell …, 2017 - nature.com
Endothelial cells and leptin receptor+ (LepR+) stromal cells are critical sources of
haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone …
haematopoietic stem cell (HSC) niche factors, including stem cell factor (SCF), in bone …
Niches for hematopoietic stem cells and their progeny
Q Wei, PS Frenette - Immunity, 2018 - cell.com
Steady-state hematopoietic stem cells'(HSCs) self-renewal and differentiation toward their
mature progeny in the adult bone marrow is tightly regulated by cues from the …
mature progeny in the adult bone marrow is tightly regulated by cues from the …
Leptin receptor+ cells promote bone marrow innervation and regeneration by synthesizing nerve growth factor
X Gao, MM Murphy, JG Peyer, Y Ni, M Yang… - Nature cell …, 2023 - nature.com
The bone marrow contains peripheral nerves that promote haematopoietic regeneration
after irradiation or chemotherapy (myeloablation), but little is known about how this is …
after irradiation or chemotherapy (myeloablation), but little is known about how this is …
The role of tumor microenvironment in multiple myeloma development and progression
A Garcia-Ortiz, Y Rodríguez-García, J Encinas… - Cancers, 2021 - mdpi.com
Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …
Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity
V Volarevic, B Djokovic, MG Jankovic… - Journal of biomedical …, 2019 - Springer
Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …
chemotherapeutic agents. However, its clinical use is limited due to the severe side effects …