Purpose of review: With the move toward development of disease modifying treatments,
there is a need for more specific diagnosis of early Alzheimer's disease (AD) and mild …

Adipose tissue has recently been recognized as an important endocrine organ that plays a
crucial role in energy metabolism and in the immune response in many metabolic tissues …

Background Functional loss of blood–brain barrier (BBB) is suggested to be pivotal to
pathogenesis and pathology of vascular-based neurodegenerative disorders such as …

Background The study aimed to validate previously discovered plasma biomarkers
associated with AD, using a design based on imaging measures as surrogate for disease …

Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by the
presence of amyloid‐β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels …

Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk
through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain …

Objectives Apolipoproteins have recently been implicated in the etiology of Alzheimer's
disease (AD). In particular, Apolipoprotein J (ApoJ or clusterin) has been proposed as a …

High-fat diet and certain dietary patterns are associated with higher incidence of sporadic
Alzheimer's disease (AD) and cognitive decline. However, no specific therapy has been …

Aims The sporadic and late-onset form of Alzheimer's disease (AD) constitutes the most
common form of dementia. This non-familiar form could be a consequence of metabolic …

Several lines of study suggest that peripheral metabolism of amyloid beta (Aß) is associated
with risk for Alzheimer disease (AD). In blood, greater than 90% of Aß is complexed as an …