[HTML][HTML] Eosinophilic esophagitis: Current concepts in diagnosis and treatment
A Gómez-Aldana, M Jaramillo-Santos… - World Journal of …, 2019 - ncbi.nlm.nih.gov
Eosinophilic esophagitis is an immune-allergic pathology of multifactorial etiology (genetic
and environmental) that affects both pediatric and adult patients. Its symptoms, which …
and environmental) that affects both pediatric and adult patients. Its symptoms, which …
[HTML][HTML] Pediatric eosinophilic esophagitis: a review for the clinician
Eosinophilic esophagitis (EoE) is a chronic clinical-pathologic disease characterized by
eosinophilic infiltration of the esophageal epithelium with esophageal dysfunction …
eosinophilic infiltration of the esophageal epithelium with esophageal dysfunction …
Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis
DM Morgan, B Ruiter, NP Smith, AA Tu, B Monian… - Science …, 2021 - science.org
Eosinophilic esophagitis (EoE) is an allergic disorder characterized by the recruitment of
eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand …
eosinophils to the esophagus, resulting in chronic inflammation. We sought to understand …
[HTML][HTML] Single-cell RNA-Seq of human esophageal epithelium in homeostasis and allergic inflammation
Inflammation of the esophageal epithelium is a hallmark of eosinophilic esophagitis (EoE),
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
an emerging chronic allergic disease. Herein, we probed human esophageal epithelial cells …
TSLP shapes the pathogenic responses of memory CD4+ T cells in eosinophilic esophagitis
Y Rochman, M Kotliar, N Ben-Baruch Morgenstern… - Science …, 2023 - science.org
The cytokine thymic stromal lymphopoietin (TSLP) mediates type 2 immune responses, and
treatments that interfere with TSLP activity are in clinical use for asthma. Here, we …
treatments that interfere with TSLP activity are in clinical use for asthma. Here, we …
Epithelial cell‐expressed type II IL‐4 receptor mediates eosinophilic esophagitis
S Avlas, G Shani, N Rhone, M Itan, A Dolitzky, I Hazut… - Allergy, 2023 - Wiley Online Library
Abstract Background Eosinophilic esophagitis (EoE) is a chronic, food‐driven allergic
disease, characterized by eosinophil‐rich inflammation in the esophagus. The …
disease, characterized by eosinophil‐rich inflammation in the esophagus. The …
Epithelial origin of eosinophilic esophagitis
M Rochman, NP Azouz, ME Rothenberg - Journal of Allergy and Clinical …, 2018 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic, allergen-driven inflammatory disease of the
esophagus characterized predominantly by eosinophilic inflammation, leading to …
esophagus characterized predominantly by eosinophilic inflammation, leading to …
The genetic etiology of eosinophilic esophagitis
LC Kottyan, S Parameswaran, MT Weirauch… - Journal of Allergy and …, 2020 - Elsevier
Eosinophilic esophagitis (EoE) is a chronic allergic disease associated with marked
mucosal eosinophil accumulation. Multiple studies have reported a strong familial …
mucosal eosinophil accumulation. Multiple studies have reported a strong familial …
Role of genetics, environment, and their interactions in the pathogenesis of eosinophilic esophagitis
J Lyles, M Rothenberg - Current opinion in immunology, 2019 - Elsevier
Highlights•FLG, DSG1, CAPN14, SPINK5, and SPINK7 elicit esophageal epithelial barrier
dysfunction.•CCL26, POSTN, and TSLP link to Th2-mediated immunity.•Environmental …
dysfunction.•CCL26, POSTN, and TSLP link to Th2-mediated immunity.•Environmental …
Replication and meta-analyses nominate numerous eosinophilic esophagitis risk genes
Background Eosinophilic esophagitis (EoE) is an emerging, chronic, rare allergic disease
associated with marked eosinophil accumulation in the esophagus. Previous genome-wide …
associated with marked eosinophil accumulation in the esophagus. Previous genome-wide …