Newcastle disease (ND) remains a constant threat to poultry producers worldwide, in spite of
the availability and global employment of ND vaccinations since the 1950s. Strains of …

CRISPR/Cas9 system genome editing is revolutionizing genetics research in a wide
spectrum of animal models in the genetic era. Among these animals, is the poultry species …

Transgenesis and genome editing in birds are based on a unique germline transmission
system using primordial germ cells (PGCs), which is quite different from the mammalian …

Due to its amenability to manipulations, to live observation and its striking similarities to
mammals, the chicken embryo has been one of the major animal models in biomedical …

Increasing evidence that mutation of planar cell polarity (PCP) genes contributes to human
cranial neural tube defect (NTD) susceptibility prompted us to hypothesize that rare variants …

This review provides an historic perspective of the key steps from those reported at the 1st
Transgenic Animal Research Conference in 1997 through to the very latest developments in …

Generating biopharmaceuticals in genetically engineered bioreactors continues to reign
supreme. Hence, genetically engineered birds have attracted considerable attention from …

Perfluorooctanoic acid (PFOA) is a persistent organic pollutant. This study established an in
ovo peroxisome proliferator-activated receptor alpha (PPAR alpha) silencing model in …

The widespread use of rodents in neuroscience has prompted the development of optimized
viral variants for transduction of brain cells, in vivo. However, many of the viruses developed …

Aim. To edit the duck genome by HDR-directed integration of the EGFP gene into the duck
host genome in combination with SMGT using CRISPR/Cas9. Methods. HDR-mediated …