The European Respiratory Society journals publish respiratory research and policy
documents of the highest quality, offering a platform for the exchange and promotion of …

Mucociliary epithelia are composed of multiciliated, secretory, and stem cells and line
various organs in vertebrates such as the respiratory tract. By means of mucociliary …

Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and causes
remodeling of the small airways. However, the exact smoke-induced effects on the different …

Background Accumulation of myofibroblasts is critical to fibrogenesis in idiopathic
pulmonary fibrosis (IPF). Senescence and insufficient mitophagy in fibroblasts contribute to …

Background Hedgehog (HH) pathway is constantly under scrutiny in the context of organ
development. Lung morphogenesis requires HH signalling which participates thereafter to …

Understanding disease-associated stem cell abnormality has major clinical implications for
prevention and treatment of human disorders, as well as for regenerative medicine. Here we …

Receptor-mediated signaling plays a central role in tissue regeneration, and it is
dysregulated in disease. Here, we build a signaling-response map for a model regenerative …

Background Bone morphogenetic proteins (BMPs), which are members of the TGF-β
superfamily, regulate bone remodeling by stimulating osteoblasts and osteoclasts. Although …

Endoglin is a membrane glycoprotein primarily expressed by the vascular endothelium and
involved in cardiovascular diseases. Upon the proteolytic processing of the membrane …

Chronic obstructive pulmonary disease (COPD) is a frequent respiratory disease. However,
its pathophysiology remains partially elucidated. Epithelial remodeling including alteration of …