The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit
The Drosophila brain contains a relatively simple circuit for forming Pavlovian associations,
yet it achieves many operations common across memory systems. Recent advances have …
yet it achieves many operations common across memory systems. Recent advances have …
Re-evaluating circuit mechanisms underlying pattern separation
NA Cayco-Gajic, RA Silver - Neuron, 2019 - cell.com
When animals interact with complex environments, their neural circuits must separate
overlapping patterns of activity that represent sensory and motor information. Pattern …
overlapping patterns of activity that represent sensory and motor information. Pattern …
Sustained deep-tissue voltage recording using a fast indicator evolved for two-photon microscopy
Genetically encoded voltage indicators are emerging tools for monitoring voltage dynamics
with cell-type specificity. However, current indicators enable a narrow range of applications …
with cell-type specificity. However, current indicators enable a narrow range of applications …
A biophysical account of multiplication by a single neuron
Nonlinear, multiplication-like operations carried out by individual nerve cells greatly
enhance the computational power of a neural system,–, but our understanding of their …
enhance the computational power of a neural system,–, but our understanding of their …
Bright and photostable chemigenetic indicators for extended in vivo voltage imaging
Genetically encoded voltage indicators (GEVIs) enable monitoring of neuronal activity at
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …
high spatial and temporal resolution. However, the utility of existing GEVIs has been limited …
A complete electron microscopy volume of the brain of adult Drosophila melanogaster
Drosophila melanogaster has a rich repertoire of innate and learned behaviors. Its 100,000-
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …
neuron brain is a large but tractable target for comprehensive neural circuit mapping. Only …
High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor
Genetically encoded voltage indicators (GEVIs) are a promising technology for fluorescence
readout of millisecond-scale neuronal dynamics. Previous GEVIs had insufficient signaling …
readout of millisecond-scale neuronal dynamics. Previous GEVIs had insufficient signaling …
Complete connectomic reconstruction of olfactory projection neurons in the fly brain
Nervous systems contain sensory neurons, local neurons, projection neurons, and motor
neurons. To understand how these building blocks form whole circuits, we must distil these …
neurons. To understand how these building blocks form whole circuits, we must distil these …
[HTML][HTML] A conserved dedicated olfactory circuit for detecting harmful microbes in Drosophila
Flies, like all animals, need to find suitable and safe food. Because the principal food source
for Drosophila melanogaster is yeast growing on fermenting fruit, flies need to distinguish …
for Drosophila melanogaster is yeast growing on fermenting fruit, flies need to distinguish …
Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila
Although associative learning has been localized to specific brain areas in many animals,
identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the …
identifying the underlying synaptic processes in vivo has been difficult. Here, we provide the …