Ibrutinib resistance mechanisms and treatment strategies for B-cell lymphomas
B George, S Mullick Chowdhury, A Hart, A Sircar… - Cancers, 2020 - mdpi.com
Chronic activation of B-cell receptor (BCR) signaling via Bruton tyrosine kinase (BTK) is
largely considered to be one of the primary mechanisms driving disease progression in B …
largely considered to be one of the primary mechanisms driving disease progression in B …
Tumor microenvironment-driven non-cell-autonomous resistance to antineoplastic treatment
Drug resistance is of great concern in cancer treatment because most effective drugs are
limited by the development of resistance following some periods of therapeutic …
limited by the development of resistance following some periods of therapeutic …
The phase 3 DUO trial: duvelisib vs ofatumumab in relapsed and refractory CLL/SLL
Duvelisib (also known as IPI-145) is an oral, dual inhibitor of phosphatidylinositol 3-kinase δ
and γ (PI3K-δ, γ) being developed for treatment of hematologic malignancies. PI3K-δ, γ …
and γ (PI3K-δ, γ) being developed for treatment of hematologic malignancies. PI3K-δ, γ …
Mesenchymal stromal cell senescence in haematological malignancies
N Plakhova, V Panagopoulos, K Vandyke… - Cancer and Metastasis …, 2023 - Springer
Acute myeloid leukaemia (AML), chronic lymphocytic leukaemia (CLL), and multiple
myeloma (MM) are age-related haematological malignancies with defined precursor states …
myeloma (MM) are age-related haematological malignancies with defined precursor states …
Importance of crosstalk between chronic lymphocytic leukemia cells and the stromal microenvironment: direct contact, soluble factors, and extracellular vesicles
N Dubois, E Crompot, N Meuleman, D Bron… - Frontiers in …, 2020 - frontiersin.org
Chronic lymphocytic leukemia (CLL) is caused by the accumulation of malignant B cells due
to a defect in apoptosis and the presence of small population of proliferating cells principally …
to a defect in apoptosis and the presence of small population of proliferating cells principally …
Chronic lymphocytic leukemia
N Chiorazzi, SS Chen, KR Rai - Cold Spring …, 2021 - perspectivesinmedicine.cshlp.org
Patients with chronic lymphocytic leukemia can be divided into three categories: those who
are minimally affected by the problem, often never requiring therapy; those that initially …
are minimally affected by the problem, often never requiring therapy; those that initially …
[HTML][HTML] Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene …
E Crompot, M Van Damme, K Pieters… - …, 2017 - ncbi.nlm.nih.gov
Interactions between chronic lymphocytic leukemia (CLL) B cells and the bone marrow (BM)
microenvironment play a major function in the physiopathology of CLL. Extracellular vesicles …
microenvironment play a major function in the physiopathology of CLL. Extracellular vesicles …
Pharmacological modulation of Kv1. 3 potassium channel selectively triggers pathological B lymphocyte apoptosis in vivo in a genetic CLL model
Background Ion channels are emerging as promising oncological targets. The potassium
channels Kv1. 3 and IKCa are highly expressed in the plasma membrane and mitochondria …
channels Kv1. 3 and IKCa are highly expressed in the plasma membrane and mitochondria …
In chronic lymphocytic leukemia the JAK2/STAT3 pathway is constitutively activated and its inhibition leads to CLL cell death unaffected by the protective bone marrow …
The bone marrow microenvironment promotes proliferation and drug resistance in chronic
lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear …
lymphocytic leukemia (CLL). Although ibrutinib is active in CLL, it is rarely able to clear …
Role of the tumor microenvironment in CLL pathogenesis
Chronic lymphocytic leukemia (CLL) cells extensively interact with and depend on their
surrounding tumor microenvironment (TME). The TME encompasses a heterogeneous array …
surrounding tumor microenvironment (TME). The TME encompasses a heterogeneous array …