Pharmacological effects of polyphenol phytochemicals on the intestinal inflammation via targeting TLR4/NF-κB signaling pathway

C Yu, D Wang, Z Yang, T Wang - International journal of molecular …, 2022 - mdpi.com
TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell
differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 …

Effects of flavonoids on intestinal inflammation, barrier integrity and changes in gut microbiota during diet-induced obesity

K Gil-Cardoso, I Ginés, M Pinent, A Ardévol… - Nutrition Research …, 2016 - cambridge.org
Diet-induced obesity is associated with low-grade inflammation, which, in most cases, leads
to the development of metabolic disorders, primarily insulin resistance and type 2 diabetes …

The potential benefit of monitoring oxidative stress and inflammation in the prevention of non-communicable diseases (NCDs)

N Seyedsadjadi, R Grant - Antioxidants, 2020 - mdpi.com
The significant increase in worldwide morbidity and mortality from non-communicable
diseases (NCDs) indicates that the efficacy of existing strategies addressing this crisis may …

Anti-inflammatory procyanidins and triterpenes in 109 apple varieties

CM Andre, JM Greenwood, EG Walker… - Journal of agricultural …, 2012 - ACS Publications
We evaluated the potential of apple to reduce inflammation. Phenolic compounds and
triterpenes were analyzed in 109 apple cultivars. Total phenolics ranged from 29 to 7882 μg …

Regulation of enteric infection and immunity by dietary proanthocyanidins

AIS Andersen-Civil, P Arora, AR Williams - Frontiers in immunology, 2021 - frontiersin.org
The role of dietary components in immune function has acquired considerable attention in
recent years. An important focus area is to unravel the role of bioactive dietary compounds in …

Procyanidins and inflammation: Molecular targets and health implications

N Martinez‐Micaelo, N González‐Abuín, A Ardevol… - Biofactors, 2012 - Wiley Online Library
The inflammatory response has been implicated in the pathogenesis of many chronic
diseases. Thus, the modulation of the inflammatory response by the consumption of …

Procyanidin B2 activates PPARγ to induce M2 polarization in mouse macrophages

Y Tian, C Yang, Q Yao, L Qian, J Liu, X Xie… - Frontiers in …, 2019 - frontiersin.org
Procyanidins, a subclass of flavonoids found in commonly consumed foods, possess
potential anti-inflammatory activity. Manipulation of M1/M2 macrophage homeostasis is an …

Effects of dietary Bacillus cereus G19, B. cereus BC-01, and Paracoccus marcusii DB11 supplementation on the growth, immune response, and expression of immune …

G Yang, X Tian, S Dong, M Peng, D Wang - Fish & shellfish immunology, 2015 - Elsevier
Probiotics have positive effects on the nutrient digestibility and absorption, immune
responses, and growth of aquatic animals, including the sea cucumber (Apostichopus …

Phenolic Acid–Amino Acid Adducts Exert Distinct Immunomodulatory Effects in Macrophages Compared to Parent Phenolic Acids

J Liu, MM Poojary, L Zhu, AR Williams… - Journal of Agricultural …, 2023 - ACS Publications
Caffeic acid (CA) and chlorogenic acid (CGA) are commonly found phenolic acids in plant-
derived foods and beverages. Their corresponding adducts with cysteine (Cys) have been …

Grape seed proanthocyanidins repress the hepatic lipid regulators miR‐33 and miR‐122 in rats

L Baselga‐Escudero, C Bladé… - Molecular nutrition & …, 2012 - Wiley Online Library
Scope One major health problem in westernized countries is dysregulated fatty acid and
cholesterol metabolism that causes pathologies such as metabolic syndrome. Previous …