G protein-coupled receptors are important drug targets that engage and activate signaling
transducers in multiple cellular compartments. Delineating therapeutic signaling from …

A striking feature of nucleic acids and lipid membranes is that they all carry net negative
charge and so is true for the majority of intracellular proteins. It is suggested that the role of …

GPCRs are master regulators of cell signaling by transducing extracellular stimuli into the
cell via selective coupling to intracellular G-proteins. Here we present a computational …

A large portion of the human GPCRome is still in the dark and understudied, consisting even
of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion …

G-protein-coupled receptors (GPCRs) activate heterotrimeric G proteins by stimulating
guanine nucleotide exchange in the Gα subunit. To visualize this mechanism, we developed …

G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …

Mammalian Ric-8 proteins act as chaperones to regulate the cellular abundance of
heterotrimeric G protein α subunits. The Ric-8A isoform chaperones Gαi/o, Gα12/13, and …

G protein-coupled receptors (GPCRs) bind to different G protein α-subtypes with varying
degrees of selectivity. The mechanism by which GPCRs achieve this selectivity is still …

Many neurotransmitter receptors activate G proteins through exchange of GDP for GTP. The
intermediate nucleotide-free state has eluded characterization, due largely to its inherent …

G protein–coupled receptors (GPCRs) regulate cellular signaling processes by coupling to
diverse combinations of heterotrimeric G proteins composed of Gα, Gβ, and Gγ subunits …