Inflammation predisposes to the development of cancer and promotes all stages of
tumorigenesis. Cancer cells, as well as surrounding stromal and inflammatory cells, engage …

The age-related dysregulation and decline of the immune system—collectively termed
“immunosenescence”—has been generally associated with an increased susceptibility to …

Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Acute inflammation is a physiological response to injury or infection, with a cascade of steps
that ultimately lead to the recruitment of immune cells to clear invading pathogens and heal …

Why do we get cancer mostly when we are old? According to current paradigms, the answer
is simple: mutations accumulate in our tissues throughout life, and some of these mutations …

Inflammation is a risk factor for cancer development. Individuals with preleukemic TET2
mutations manifest clonal hematopoiesis and are at a higher risk of developing leukemia …

Aging and chronic inflammation are independent risk factors for the development of
atherothrombosis and cardiovascular disease. We hypothesized that aging-associated …

Hematopoietic stem cells (HSCs) are responsible for lifelong production of blood cells. At the
same time, they must respond rapidly to acute needs such as infection or injury. Significant …

IL‐37 is a unique member of the IL‐1 family of cytokines, which functions as a natural
suppressor of inflammatory and immune responses. Immune and non‐immune cells …

Acute kidney injury (AKI) is a common clinical state resulting from pathogenic conditions
such as ischemic and toxic insults. The pathophysiology of AKI shares common pathogenic …