Transcription initiation is a major regulatory step in eukaryotic gene expression. It involves
the assembly of general transcription factors and RNA polymerase II into a functional pre …

From yeast to human, the Spt-Ada-GCN5-acetyltransferase (SAGA) gigantic complex
modifies chromatin during RNA polymerase II initiation and elongation steps to facilitate …

DE-ETIOLATED 1 (DET1) is an evolutionarily conserved component of the ubiquitination
machinery that mediates the destabilization of key regulators of cell differentiation and …

Abstract The SAGA (Spt-Ada-Gcn5 acetyltransferase) complex is an evolutionarily
conserved histone acetyltransferase complex that has a critical role in histone acetylation …

Epigenetic mechanisms play diverse roles in the regulation of genome stability in
eukaryotes. In Arabidopsis thaliana, genome stability is maintained during DNA replication …

Protein complexes involved in epigenetic regulation of transcription have evolved as
molecular strategies to face environmental stress in plants. SAGA (Spt–Ada–Gcn5 …

Nuclear pore complexes (NPCs) are large multi-protein complexes that control bidirectional
trafficking of macromolecules between the nucleus and cytoplasm. This trafficking is highly …

The SAGA complex is an evolutionarily conserved transcriptional coactivator that regulates
gene expression through its histone acetyltransferase and deubiquitylase activities …

Covalent modification of histones is an important tool for gene transcriptional control in
eukaryotes, which coordinates growth, development, and adaptation to environmental …

The basal transcription factor TFIID is central for RNA polymerase II-dependent transcription.
Human TFIID is endowed with chromatin reader and DNA-binding domains and protein …