In women, the non-growing population of follicles that comprise the ovarian reserve is
determined at birth and serves as the reservoir for future fertility. This reserve of dormant …

Across the Western World there is an increasing trend to postpone childbearing.
Consequently, the negative influence of age on oocyte quality may lead to a difficulty in …

Molecular mechanisms of ovarian aging and female age-related fertility decline remain
unclear. We surveyed the single-cell transcriptomic landscape of ovaries from young and …

The fetal basis of adult disease is poorly understood on a molecular level and cannot be
solely attributed to genetic mutations or a single etiology. Embryonic exposure to …

In the last decade, nanotechnology has been extensively introduced for biomedical
applications, including bio-detection, drug delivery and diagnostic imaging, particularly in …

The actions of environmental toxicants and relevant mixtures in promoting the epigenetic
transgenerational inheritance of ovarian disease was investigated with the use of a …

Infertility is a relatively common health condition, affecting nearly 7% of all couples.
Clinically, it is a highly heterogeneous pathology with a complex etiology that includes …

The adult mammalian ovary is devoid of definitive germline stem cells. As such, female
reproductive senescence largely results from the depletion of a finite ovarian follicle pool …

Primary ovarian insufficiency (POI) is defined as a reduction in ovarian function before the
expected age of menopause. POI is known to increase the risk of cardiovascular disorders …

The prevalence of obesity is high among reproductive-age women and is associated with
impaired reproductive function. Obesity is multifactorial in origin, yet many cases of obesity …