Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …

Recombination is a central biological process with implications for many areas in the life
sciences. Yet we are only beginning to appreciate variation in the recombination rate along …

Motivation Coexisting in a DNA system, meiosis and recombination are two indispensible
aspects for cell reproduction and growth. With the avalanche of genome sequences …

The malaria parasite Plasmodium falciparum has a great capacity for evolutionary
adaptation to evade host immunity and develop drug resistance. Current understanding of …

Theileria parasites infect a wide range of domestic and wild ruminants worldwide, causing
diseases with varying degrees of severity. A broad classification, based on the parasite's …

The variant antigen Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1),
which is expressed on the surface of P. falciparum-infected red blood cells, is a critical …

GC-biased gene conversion (gBGC) is a process that tends to increase the GC content of
recombining DNA over evolutionary time and is thought to explain the evolution of GC …

Acquired immunity in vertebrates maintains polymorphisms in endemic pathogens, leading
to identifiable signatures of balancing selection. To comprehensively survey for genes under …

In high-transmission regions, we expect parasite lineages within complex malaria infections
to be unrelated due to parasite inoculations from different mosquitoes. This project was …

Research into the complex genetic underpinnings of the malaria parasite Plasmodium
falciparum is entering a new era with the arrival of site-specific genome engineering …