[HTML][HTML] Manipulating gene expression levels in mammalian cell factories: an outline of synthetic molecular toolboxes to achieve multiplexed control
P Eisenhut, N Marx, G Borsi, M Papež, C Ruggeri… - New …, 2023 - Elsevier
Cells, both of prokaryotic and eukaryotic origin, have developed dedicated molecular
mechanisms to tightly control expression levels of their genes where the specific …
mechanisms to tightly control expression levels of their genes where the specific …
[HTML][HTML] A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells
V Schmieder, N Novak, H Dhiman, LN Nguyen… - Biotechnology …, 2021 - Elsevier
Chinese hamster ovary (CHO) cells are the most widely used host for the expression of
therapeutic proteins. Recently, significant progress has been made due to advances in …
therapeutic proteins. Recently, significant progress has been made due to advances in …