The B cell lymphoma 2–associated anthanogene (BAG3) is an anti-apoptotic co-chaperone
protein. Previous reports suggest that mutations in BAG3 are associated with dilated …

SARS-CoV-2 is a newly identified coronavirus that causes the respiratory disease called
coronavirus disease 2019 (COVID-19). With an urgent need for therapeutics, we lack a full …

Over the past two decades, with the advent and adoption of highly active anti-retroviral
therapy, HIV-1 infection, a once fatal and acute illness, has transformed into a chronic …

Objectives To evaluate the risk of heart failure (HF) linked to human immunodeficiency virus
(HIV) infection, how risk varies by demographic characteristics, and whether it is explained …

The treatment of pediatric heart failure is a long-standing unmet medical need. Angiotensin II
supports mammalian perinatal circulation by activating cardiac L-type Ca2+ channels …

Varying degrees of cognitive deficits affect over half of all HIV-1 infected patients. Because of
antiretroviral treatment (ART) regimens, the HIV-1 patient population is increasing in age …

Homeostasis in vertebrate systems is contingent on normal cardiac function. This, in turn,
depends on intricate protein-based cellular machinery, both for contractile function, as well …

HIV disease remains prevalent in the USA and chronic kidney disease remains a major
cause of morbidity in HIV-1-positive patients. Host double-stranded RNA (dsRNA)-activated …

Mitochondrial dysfunction is a very plausible driver of adverse ageing phenotypes in some
older PLWH. As such it may be a target for therapeutic interventions. Currently, however …

Aims Human immunodeficiency virus (HIV) increases the risk of heart failure (HF), but
whether it influences subsequent morbidity and mortality remains unclear. Methods and …