Tumour fatty acid metabolism in the context of therapy resistance and obesity

AJ Hoy, SR Nagarajan, LM Butler - Nature Reviews Cancer, 2021 - nature.com
Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Bone metastasis: mechanisms, therapies, and biomarkers

P Clézardin, R Coleman, M Puppo… - Physiological …, 2021 - journals.physiology.org
Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

A Yang, EP Mottillo - Biochemical Journal, 2020 - portlandpress.com
Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …

[HTML][HTML] CCL2: an important mediator between tumor cells and host cells in tumor microenvironment

J Jin, J Lin, A Xu, J Lou, C Qian, X Li, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME
consists of a considerable number of macrophages and stromal cells that have been …

Interaction between adipose tissue and cancer cells: role for cancer progression

JF Dumas, L Brisson - Cancer and Metastasis Reviews, 2021 - Springer
Environment surrounding tumours are now recognized to play an important role in tumour
development and progression. Among the cells found in the tumour environment, adipocytes …

Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF‐1 upregulation of TUBB2B beta‐tubulin isoform

A Liotti, E La Civita, M Cennamo, F Crocetto… - The …, 2021 - Wiley Online Library
Growing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in
prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect …

[HTML][HTML] The role of inflammation in breast and prostate cancer metastasis to bone

A Göbel, S Dell'Endice, N Jaschke, S Pählig… - International Journal of …, 2021 - mdpi.com
Tumor metastasis to bone is a common event in multiple forms of malignancy. Inflammation
holds essential functions in homeostasis as a defense mechanism against infections and is …

[HTML][HTML] Role of bone marrow adipocytes in bone metastasis development and progression: a systematic review

F Salamanna, D Contartese, C Errani… - Frontiers in …, 2023 - frontiersin.org
Purpose Bone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow
and function as an endocrine organ by producing fatty acids, cytokines, and adipokines …

[HTML][HTML] Bone marrow adipocytes: A link between obesity and bone cancer

MR Reagan, H Fairfield, CJ Rosen - Cancers, 2021 - mdpi.com
Simple Summary This review discusses the important newly-established roles for bone
marrow adipose tissue in cancer progression and highlights the research demonstrating …

Fat quantification: Imaging methods and clinical applications in cancer

SY Yan, YW Yang, XY Jiang, S Hu, YY Su… - European Journal of …, 2023 - Elsevier
Recently, the study of the relationship between lipid metabolism and cancer has evolved.
The characteristics of intratumoral and peritumoral fat are distinct and changeable during …