Tumour fatty acid metabolism in the context of therapy resistance and obesity
Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …
Bone metastasis: mechanisms, therapies, and biomarkers
Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …
Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics
A Yang, EP Mottillo - Biochemical Journal, 2020 - portlandpress.com
Fatty acids (FAs) are stored safely in the form of triacylglycerol (TAG) in lipid droplet (LD)
organelles by professional storage cells called adipocytes. These lipids are mobilized …
organelles by professional storage cells called adipocytes. These lipids are mobilized …
[HTML][HTML] CCL2: an important mediator between tumor cells and host cells in tumor microenvironment
J Jin, J Lin, A Xu, J Lou, C Qian, X Li, Y Wang… - Frontiers in …, 2021 - frontiersin.org
Tumor microenvironment (TME) formation is a major cause of immunosuppression. The TME
consists of a considerable number of macrophages and stromal cells that have been …
consists of a considerable number of macrophages and stromal cells that have been …
Interaction between adipose tissue and cancer cells: role for cancer progression
JF Dumas, L Brisson - Cancer and Metastasis Reviews, 2021 - Springer
Environment surrounding tumours are now recognized to play an important role in tumour
development and progression. Among the cells found in the tumour environment, adipocytes …
development and progression. Among the cells found in the tumour environment, adipocytes …
Periprostatic adipose tissue promotes prostate cancer resistance to docetaxel by paracrine IGF‐1 upregulation of TUBB2B beta‐tubulin isoform
A Liotti, E La Civita, M Cennamo, F Crocetto… - The …, 2021 - Wiley Online Library
Growing evidence supports the pivotal role played by periprostatic adipose tissue (PPAT) in
prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect …
prostate cancer (PCa) microenvironment. We investigated whether PPAT can affect …
[HTML][HTML] The role of inflammation in breast and prostate cancer metastasis to bone
A Göbel, S Dell'Endice, N Jaschke, S Pählig… - International Journal of …, 2021 - mdpi.com
Tumor metastasis to bone is a common event in multiple forms of malignancy. Inflammation
holds essential functions in homeostasis as a defense mechanism against infections and is …
holds essential functions in homeostasis as a defense mechanism against infections and is …
[HTML][HTML] Role of bone marrow adipocytes in bone metastasis development and progression: a systematic review
F Salamanna, D Contartese, C Errani… - Frontiers in …, 2023 - frontiersin.org
Purpose Bone marrow adipocytes (BMAs) are the most plentiful cells in the bone marrow
and function as an endocrine organ by producing fatty acids, cytokines, and adipokines …
and function as an endocrine organ by producing fatty acids, cytokines, and adipokines …
[HTML][HTML] Bone marrow adipocytes: A link between obesity and bone cancer
Simple Summary This review discusses the important newly-established roles for bone
marrow adipose tissue in cancer progression and highlights the research demonstrating …
marrow adipose tissue in cancer progression and highlights the research demonstrating …
Fat quantification: Imaging methods and clinical applications in cancer
SY Yan, YW Yang, XY Jiang, S Hu, YY Su… - European Journal of …, 2023 - Elsevier
Recently, the study of the relationship between lipid metabolism and cancer has evolved.
The characteristics of intratumoral and peritumoral fat are distinct and changeable during …
The characteristics of intratumoral and peritumoral fat are distinct and changeable during …