Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview
Matrix metalloproteinases (MMPs) are zinc dependent proteolytic metalloenzyme. MMP-9 is
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
one of the most complex forms of matrix metalloproteinases. MMP-9 has the ability to …
Is there new hope for therapeutic matrix metalloproteinase inhibition?
RE Vandenbroucke, C Libert - Nature reviews Drug discovery, 2014 - nature.com
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that form a family of
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …
24 members in mammals. Evidence of the pathological roles of MMPs in various diseases …
MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines
Human mesenchymal stem cells (hMSCs) represent promising tools in various clinical
applications, including the regeneration of injured tissues by endogenous or transplanted …
applications, including the regeneration of injured tissues by endogenous or transplanted …
Gelatinase-mediated migration and invasion of cancer cells
M Björklund, E Koivunen - Biochimica et Biophysica Acta (BBA)-Reviews …, 2005 - Elsevier
The matrix metalloproteinases (MMP)-2 and-9, also known as the gelatinases have been
long recognized as major contributors to the proteolytic degradation of extracellular matrix …
long recognized as major contributors to the proteolytic degradation of extracellular matrix …
Matrix metalloproteinase inhibitors as investigational and therapeutic tools in unrestrained tissue remodeling and pathological disorders
J Liu, RA Khalil - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes that degrade
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
various proteins in the extracellular matrix (ECM). MMPs may also regulate the activity of …
[HTML][HTML] To bind zinc or not to bind zinc: an examination of innovative approaches to improved metalloproteinase inhibition
JA Jacobsen, JLM Jourden, MT Miller… - Biochimica et Biophysica …, 2010 - Elsevier
This short review highlights some recent advances in matrix metalloproteinase inhibitor
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …
(MMPi) design and development. Three distinct approaches to improved MMP inhibition are …
Matrix metalloproteinase inhibitors as investigative tools in the pathogenesis and management of vascular disease
MM Benjamin, RA Khalil - … Inhibitors: Specificity of Binding and Structure …, 2012 - Springer
Matrix metalloproteinases (MMPs) are proteolytic enzymes that degrade various
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …
components of the extracellular matrix (ECM). MMPs could also regulate the activity of …
Recent advances in MMP inhibitor design
JF Fisher, S Mobashery - Cancer and Metastasis Reviews, 2006 - Springer
The search for an MMP inhibitor with anticancer efficacy is a nearly three-decade endeavor.
This inhibitor is yet to be found. The reasons for this failure include shortcomings in the …
This inhibitor is yet to be found. The reasons for this failure include shortcomings in the …
Matrix metalloproteinase inhibition therapy for vascular diseases
AC Newby - Vascular pharmacology, 2012 - Elsevier
The matrix metalloproteinases (MMPs) are 23 secreted or cell surface proteases that act
together and with other protease classes to turn over the extracellular matrix, cleave cell …
together and with other protease classes to turn over the extracellular matrix, cleave cell …
Matrix metalloproteinase inhibitors: a critical appraisal of design principles and proposed therapeutic utility
Matrix metalloproteinases (MMPs) play an important role in tissue remodelling associated
with various physiological and pathological processes, such as morphogenesis …
with various physiological and pathological processes, such as morphogenesis …