• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The aorta is the 'greatest artery', through which oxygenated blood is delivered from the left
ventricle to end organs with each cardiac cycle (200 million litres of blood transported in an …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

Purpose Marfan syndrome (MFS) is a connective tissue disorder in which several systems
are affected with great phenotypic variability. Although known to be associated with …

Imaging techniques play a pivotal role in the diagnosis, follow-up, and management of aortic
diseases. Multimodality imaging provides complementary and essential information for this …

These guidelines, endorsed by both the EACTS and STS, represent the official viewpoint on
this topic. They show a commitment to ongoing improvement, as regular updates will be …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

Thoracic aortic aneurysm and aortic dissection have a potent genetic underpinning with
20% of individuals having an affected relative. Heritable thoracic aortic diseases (HTAD) …

Myocardial infarction in the absence of obstructive coronary artery disease (MINOCA) is an
important subtype of myocardial infarction. Although comprising less than 50% stenosis in …

Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein
encoded by FBN1 gene. It serves as a structural component of microfibrils and provides …