The broadening scope of oral mucositis and oral ulcerative mucosal toxicities of anticancer therapies

S Elad, N Yarom, Y Zadik… - CA: a cancer journal …, 2022 - Wiley Online Library
Oral mucositis (OM) is a common, highly symptomatic complication of cancer therapy that
affects patients' function, quality of life, and ability to tolerate treatment. In certain patients …

[HTML][HTML] Comparative analysis of BTK inhibitors and mechanisms underlying adverse effects

HY Estupiñán, A Berglöf, R Zain… - Frontiers in cell and …, 2021 - frontiersin.org
The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and
survival of B-lineage cells and, hence, represents a suitable drug target. The number of BTK …

Dermatological toxicities of Bruton's tyrosine kinase inhibitors

V Sibaud, M Beylot-Barry, C Protin, E Vigarios… - American Journal of …, 2020 - Springer
The development of Bruton's tyrosine kinase (BTK) inhibitors represents a major
breakthrough in the treatment of chronic lymphocytic leukemia and other B cell …

[HTML][HTML] Multifaceted immunomodulatory effects of the BTK inhibitors ibrutinib and acalabrutinib on different immune cell subsets–beyond B lymphocytes

S Zhu, S Gokhale, J Jung, E Spirollari, J Tsai… - Frontiers in cell and …, 2021 - frontiersin.org
The clinical success of the two BTK inhibitors, ibrutinib and acalabrutinib, represents a major
breakthrough in the treatment of chronic lymphocytic leukemia (CLL) and has also …

Ibrutinib-associated dermatologic toxicities: A systematic review and meta-analysis

S Nocco, TM Andriano, A Bose, M Chilov… - Critical Reviews in …, 2022 - Elsevier
The scope of dermatologic adverse events to ibrutinib has not been systematically
described. We sought to determine the incidence and severity of ibrutinib-associated …

Diverse landscape of dermatologic toxicities from small‐molecule inhibitor cancer therapy

RNH Seervai, WC Cho, EY Chu… - Journal of cutaneous …, 2022 - Wiley Online Library
Background Advances in molecular biology and genetics have contributed to breakthrough
treatments directed at specific pathways associated with the development of cancer. Small …

Chronic lymphocytic leukemia and the skin: implications for the dermatologist

LJ Fried, MC Criscito, ML Stevenson… - International Journal …, 2022 - Wiley Online Library
B‐cell chronic lymphocytic leukemia (CLL) is the most prevalent leukemia in the United
States, and its diagnosis can have many dermatologic implications. For one, the cutaneous …

Cutaneous adverse‐events in patients treated with Ibrutinib

A Pileri, A Guglielmo, C Agostinelli… - Dermatologic …, 2020 - Wiley Online Library
Ibrutinib is a Burton tyrosine kinase inhibitor (BTKi) approved for the treatment of several
hematologic malignancies. Analyze skin adverse events (SAE). All the patients treated with …

Bruton's tyrosine kinase (BTK) inhibitors for the treatment of primary central nervous system lymphoma (PCNSL): current progress and latest advances

L Schaff, L Nayak, C Grommes - Leukemia & Lymphoma, 2024 - Taylor & Francis
The incidence of primary central nervous system lymphoma (PCNSL) has steadily
increased, particularly in elderly patients. Although highly responsive to first-line …

Ibrutinib plus rituximab for the treatment of adult patients with Waldenström's macroglobulinemia: a safety evaluation

M Migkou, D Fotiou, M Gavriatopoulou… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: Waldenström's macroglobulinemia (WM), an orphan disease, is a rare low-
grade B-cell lymphoplasmacytic lymphoma with unique clinical features and monoclonal …