Cytokines and chemokines involved in osteoarthritis pathogenesis
Osteoarthritis is a common cause of disability worldwide. Although commonly referred to as
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …
a disease of the joint cartilage, osteoarthritis affects all joint tissues equally. The …
T-cell mediated inflammation in postmenopausal osteoporosis
D Wu, A Cline-Smith, E Shashkova, A Perla… - Frontiers in …, 2021 - frontiersin.org
Osteoporosis is the most prevalent metabolic bone disease that affects half the women in the
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …
sixth and seventh decade of life. Osteoporosis is characterized by uncoupled bone …
IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis
Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases
including osteoarthritis (OA), in part via expression of a senescence-associated secretory …
including osteoarthritis (OA), in part via expression of a senescence-associated secretory …
IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice
Although sex dimorphism is increasingly recognized as an important factor in pain, female-
specific pain signaling is not well studied. Here we report that administration of IL-23 …
specific pain signaling is not well studied. Here we report that administration of IL-23 …
A dysfunctional TRPV4–GSK3β pathway prevents osteoarthritic chondrocytes from sensing changes in extracellular matrix viscoelasticity
Abstract Changes in the composition and viscoelasticity of the extracellular matrix in load-
bearing cartilage influence the proliferation and phenotypes of chondrocytes, and are …
bearing cartilage influence the proliferation and phenotypes of chondrocytes, and are …
Intra-articular injection of culture-expanded mesenchymal stem cells with or without addition of platelet-rich plasma is effective in decreasing pain and symptoms in …
Purpose To compare the clinical and laboratory outcomes of intra-articular injections of
culture-expanded bone-derived mesenchymal stem cells (MSCs) with or without platelet-rich …
culture-expanded bone-derived mesenchymal stem cells (MSCs) with or without platelet-rich …
[PDF][PDF] JAK/STAT pathway and nociceptive cytokine signalling in rheumatoid arthritis and psoriatic arthritis
N Crispino, F Ciccia - Clin Exp Rheumatol, 2021 - clinexprheumatol.org
The key role of pro-inflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA)
and psoriatic arthritis (PsA) is strongly supported by the observation that their blockage is …
and psoriatic arthritis (PsA) is strongly supported by the observation that their blockage is …
The association between vitamin D concentration and pain: a systematic review and meta-analysis
ObjectivePain-related conditions, such as chronic widespread pain and fibromyalgia, are
major burdens for individuals and the health system. Evidence from previous research on …
major burdens for individuals and the health system. Evidence from previous research on …
The role of magnesium in different inflammatory diseases
Magnesium deficiency (MgD) can cause inflammation in human body. The known
mechanisms of inflammation caused by MgD include activation of phagocytic cells, opening …
mechanisms of inflammation caused by MgD include activation of phagocytic cells, opening …
Interleukin-1-interleukin-17 signaling axis induces cartilage destruction and promotes experimental osteoarthritis
HS Na, JS Park, KH Cho, JY Kwon, JW Choi… - Frontiers in …, 2020 - frontiersin.org
Osteoarthritis (OA), which is the most common degenerative joint disorder, has been
considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a …
considered a non-inflammatory disease with abnormal mechanics. Interleukin (IL)-17 is a …