Multicomponent Synthesis of 1,3-Diketone-Linked N-Substituted Pyrroles, Pyrrolo[1,2-a]pyrazines, Pyrrolo[1,4]diazepines, and Pyrrolo[1,4]diazocines

S Chithanna, DY Yang - The Journal of Organic Chemistry, 2019 - ACS Publications
A new methodology is developed for the efficient synthesis of 1, 3-diketone-linked N-
substituted pyrroles, pyrrolo [1, 2-a] pyrazines, pyrrolo [1, 4] diazepines, and pyrrolo [1, 4] …

A Route to (Het)arene-Annulated Pyrrolo[1,2-d][1,4]diazepines via the Expanded Intramolecular Paal–Knorr Reaction: Nitro Group and Furan Ring as Equivalents of …

EY Zelina, TA Nevolina, DA Skvortsov… - The Journal of …, 2019 - ACS Publications
A straightforward protocol toward pharmacologically relevant (het) areno [x, yb] pyrrolo [1, 2-
d][1, 4] diazepines in good to high yields has been described. The designed approach …

A General Synthetic Route to Isomeric Pyrrolo[1,2-x][1,4]diazepinones

EY Zelina, TA Nevolina, LN Sorotskaja… - The Journal of …, 2018 - ACS Publications
A simple one-pot method for the synthesis of isomeric pyrrolo [1, 2-x][1, 4] diazepinones in
reasonable yields was developed. The method is based on the condensation of readily …

Furan ring opening-pyrrole ring closure: A new route to pyrrolo [1, 2-d][1, 4] benzodiazepin-6-ones

TA Nevolina, VA Shcherbinin, OV Serdyuk… - Synthesis, 2011 - thieme-connect.com
A new method for the synthesis of pyrrolo [1, 2-d][1, 4] benzodiazepines is described. The
method is based on the acid-catalyzed recyclization of N-[2-(5-alkyl-2-furyl) phenyl]-2 …

An efficient approach to the synthesis of alkyl 7-hydroxy-1-oxo-1, 2, 3, 4-tetrahydropyrrolo [1, 2-a] pyrazine-8-carboxylates via a one-pot, three-component reaction

A Alizadeh, MH Abadi, R Ghanbaripour - Synlett, 2014 - thieme-connect.com
An efficient synthesis of alkyl 7-hydroxy-1-oxo-1, 2, 3, 4-tetrahydropyrrolo [1, 2-a] pyrazine-8-
carboxylate derivatives by reaction between diamines, dialkyl acetylenedicarboxylates, and …

Synthesis of Polyfunctionalized Pyrroles from Furfurylamines and Ynones via CuCl2-Catalyzed and Iodine-Mediated Oxidative Annulation of N-Furfuryl-β-enaminones

J Zou, G Zeng, R Yang, B Yin - Synthesis, 2017 - thieme-connect.com
The copper chloride catalyzed and iodine-mediated oxidative annulation of N-furfuryl-β-
enaminones, generated in situ from reactions of furfurylamines with ynones, provides a …

An efficient one pot three‐component domino reaction for the synthesis of 1, 3, 4‐trisubstituted pyrroles

SV Kumar, S Muthusaravanan… - …, 2016 - Wiley Online Library
Abstract An efficient synthesis of 1, 3, 4‐trisubstituted pyrroles via three‐component domino
reactions of (E)‐3‐(dimethylamino)‐1‐arylprop‐2‐en‐1‐ones, anilines and β‐nitrostyrenes …

Protolytic opening of the furan ring in the synthesis of 5H,10H-dipyrrolo[1,2-a:1',2'-d]pyrazines

TA Nevolina, VA Shcherbinin, PM Shpuntov… - Chemistry of …, 2012 - Springer
One of the most important properties of furan compounds widely used in synthetic practice is
their ability to undergo ring opening to form 1, 4-diketones [1]. Hence the protolytic opening …

Short approach to pyrrolopyrazino-, pyrrolodiazepino-isoindoles and their benzo analogues via the IMDAF reaction

FI Zubkov, DN Orlova, VP Zaytsev… - Current Organic …, 2017 - ingentaconnect.com
Aim and Objective: A new approach to synthesis of isoindoles condensed with other
heterocycles and revelation of their spatial structure for biochemistry purposes was the main …

Tandem homologation-acylation chemistry: Single and double homologation

CS Henderson, JR Mazzone, AM Moore, CK Zercher - Tetrahedron, 2021 - Elsevier
Abstract Treatment of β-dicarbonyls with the Furakawa-variant of the Simmons-Smith
reagent results in homologation and production of an intermediate zinc enolate. Treatment …