It is well known that most brain disorders are complex diseases, such as Alzheimer's
disease (AD) and schizophrenia (SCZ). In general, brain regions and their interactions can …

Genes that are thought to be critical for the survival of organisms or cells are called essential
genes. The prediction of essential genes and their products (essential proteins) is of great …

Background and scope Nowadays, centrality analysis has become a principal method for
identifying essential proteins in biological networks. Here we present CytoNCA, a Cytoscape …

Essential proteins are vital for an organism's viability under a variety of conditions. There are
many experimental and computational methods developed to identify essential proteins …

Computational methods including centrality and machine learning-based methods have
been proposed to identify essential proteins for understanding the minimum requirements of …

A biological network is complex. A group of critical nodes determines the quality and state of
such a network. Increasing studies have shown that diseases and biological networks are …

Identifying essential proteins plays an important role in disease study, drug design, and
understanding the minimal requirement for cellular life. Computational methods for essential …

Background Some proposed methods for identifying essential proteins have better results by
using biological information. Gene expression data is generally used to identify essential …

Essential proteins are indispensable for cellular life. It is of great significance to identify
essential proteins that can help us understand the minimal requirements for cellular life and …

Essential proteins are indispensable for the survival or reproduction of an organism.
Identification of essential proteins is not only necessary for the understanding of the minimal …