Tuberculosis still remains one of the most common, communicable, and leading deadliest
diseases known to mankind throughout the world. Drug-resistance in Mycobacterium …

A novel series of benzothiazole-based derivatives linked to various amino acids and their
corresponding ethyl ester analogues were prepared and were initially evaluated for their …

Natural-based drugs are believed to be safe, effective and economical. Based on the
medicinal importance of the genus Eryngium and unexplored nature of Eryngium …

Dual inhibition of the enzymatic pathways of cyclooxygenases (COX-1/COX-2) and
lipoxygenase (LOX) is a rational approach for developing more efficient and safe anti …

With the rising levels of drug resistance, developing efficient antimicrobial therapies has
become a priority. A promising strategy is the conjugation of antibiotics with relevant …

A new class of fused quinazolines has been designed and synthesized via copper-catalyzed
Ullmann type C–N coupling followed by intramolecular cross-dehydrogenative coupling …

This article summarizes the most recent advancements in the synthetic and pharmacological
approaches along with the structure activity relationship towards the s-triazine and its …

Abstract A series of 5-nitrofuran-2-yl-thiadiazole linked to different cyclohexyl-2-
(phenylamino) acetamides were rationally designed and synthesized. All synthetic …

Nitroimidazoles based compounds remain a hot topic of research in medicinal chemistry
due to their numerous biological activities. Moreover, many clinical candidates based on this …

To tackle leishmaniasis, search for efficient therapeutic drug targets should be pursued.
Dihydrofolate reductase (DHFR) is considered as a key target for the treatment of …