Progressive liver fibrosis in non-alcoholic fatty liver disease

D Ramai, A Facciorusso, E Vigandt, B Schaf… - Cells, 2021 - mdpi.com
Non-alcoholic steatohepatitis (NASH) is a chronic and progressive form of non-alcoholic
fatty liver disease. Its global incidence is increasing and makes NASH an epidemic and a …

Structures, sources, identification/quantification methods, health benefits, bioaccessibility, and products of isorhamnetin glycosides as phytonutrients

H Wang, L Chen, B Yang, J Du, L Chen, Y Li, F Guo - Nutrients, 2023 - mdpi.com
In recent years, people have tended to consume phytonutrients and nutrients in their daily
diets. Isorhamnetin glycosides (IGs) are an essential class of flavonoids derived from dietary …

Crosstalk between NK cells and hepatic stellate cells in liver fibrosis

Y Zhang, Y Wu, W Shen… - Molecular medicine …, 2022 - spandidos-publications.com
Liver fibrosis is a common pathological process of chronic liver diseases, including viral
hepatitis and alcoholic liver disease, and ultimately progresses to irreversible cirrhosis and …

Immune response and treatment targets of chronic hepatitis B virus infection: Innate and adaptive immunity

P Zheng, Y Dou, Q Wang - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Chronic hepatitis B virus (HBV) infection is a major global public health risk that threatens
human life and health, although the number of vaccinated people has increased. The …

The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells

AE Ziegler, P Fittje, LM Müller, AE Ahrenstorf… - Frontiers in …, 2023 - frontiersin.org
The crosstalk between NK cells and their surrounding environment is enabled through
activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory …

NK cells and other cytotoxic innate lymphocytes in colorectal cancer progression and metastasis

C Fionda, G Scarno, H Stabile, R Molfetta… - International journal of …, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most common malignancies and leading causes of
cancer-related deaths worldwide. Despite its complex pathogenesis and progression, CRC …

Natural killer cells in hepatic ischemia-reperfusion injury

M Huang, H Cai, B Han, Y Xia, X Kong… - Frontiers in …, 2022 - frontiersin.org
Ischemia-reperfusion injury can be divided into two phases, including insufficient supply of
oxygen and nutrients in the first stage and then organ injury caused by immune inflammation …

Liver-resident memory T cells: life in lockdown

LJ Pallett, MK Maini - Seminars in Immunopathology, 2022 - Springer
A subset of memory T cells has been identified in the liver with a tissue-resident profile and
the capacity for long-term 'lockdown'. Here we review how they are retained in, and adapted …

Role of gut microbiota and immune cells in metabolic-associated fatty liver disease: Clinical impact

A Alisi, G McCaughan, H Grønbæk - Hepatology international, 2024 - Springer
In 2020, a revised definition of fatty liver disease associated with metabolic dysfunction
(MAFLD) was proposed to replace non-alcoholic fatty liver (NAFLD). Liver steatosis and at …

[HTML][HTML] Targeted Drug Delivery Strategies for the Treatment of Hepatocellular Carcinoma

Y Liu, Y Wu, Z Li, D Wan, J Pan - Molecules, 2024 - mdpi.com
Hepatocellular carcinoma (HCC) ranks among the most prevalent malignant tumors,
exhibiting a high incidence rate that presents a substantial threat to human health. The use …