In order to understand how the molecular or cellular defects that underlie a disease of the
nervous system lead to the observable symptoms, it is necessary to develop a large‐scale …

A commonly observed neural correlate of working memory is firing that persists after the
triggering stimulus disappears. Substantial effort has been devoted to understanding the …

TRP proteins are cation channels responding to receptor-dependent activation of
phospholipase C. Mammalian (TRPC) channels can form hetero-oligomeric channels in …

Mnemonic persistent activity in the prefrontal cortex (PFC) constitutes the neural basis of
working memory. To understand how neuromodulators contribute to the generation of …

Mammalian short TRP channels (TRPCs) are putative receptor-and store-operated cation
channels that play a fundamental role in the regulation of cellular Ca 2+ homeostasis …

Dopamine D2 receptors (D2Rs) play a major role in the function of the prefrontal cortex
(PFC), and may contribute to prefrontal dysfunction in conditions such as schizophrenia …

Mammals can reliably predict the time of occurrence of an expected event after a predictive
stimulus. Climbing activity is a prominent profile of neural activity observed in prefrontal …

In addition to innervating the cerebral cortex, basal forebrain cholinergic (BFc) neurons send
a dense projection to the basolateral nucleus of the amygdala (BLA). In this study, we …

The seven mammalian channels from the classical (TRPC) subfamily of transient receptor
potential (TRP) channels are thought to be receptor-operated cation channels activated in a …

Activation of muscarinic cholinergic receptors on pyramidal cells of the cerebral cortex
induces the appearance of a slow afterdepolarization that can sustain autonomous spiking …