Refinement of Singer-Nicolson fluid-mosaic model by microscopy imaging: Lipid rafts and actin-induced membrane compartmentalization

KGN Suzuki, A Kusumi - Biochimica et Biophysica Acta (BBA) …, 2023 - Elsevier
This year celebrates the 50th anniversary of the Singer-Nicolson fluid mosaic model for
biological membranes. The next level of sophistication we have achieved for understanding …

Mechanisms underlying anomalous diffusion in the plasma membrane

D Krapf - Current topics in membranes, 2015 - Elsevier
The plasma membrane is a complex fluid where lipids and proteins undergo diffusive motion
critical to biochemical reactions. Through quantitative imaging analyses such as single …

Confined diffusion of transmembrane proteins and lipids induced by the same actin meshwork lining the plasma membrane

TK Fujiwara, K Iwasawa, Z Kalay… - Molecular biology of …, 2016 - Am Soc Cell Biol
The mechanisms by which the diffusion rate in the plasma membrane (PM) is regulated
remain unresolved, despite their importance in spatially regulating the reaction rates in the …

[HTML][HTML] Glycosylation-dependent IFN-γR partitioning in lipid and actin nanodomains is critical for JAK activation

CM Blouin, Y Hamon, P Gonnord, C Boularan, J Kagan… - Cell, 2016 - cell.com
Understanding how membrane nanoscale organization controls transmembrane receptors
signaling activity remains a challenge. We studied interferon-γ receptor (IFN-γR) signaling in …

Diffusion of GPI-anchored proteins is influenced by the activity of dynamic cortical actin

S Saha, IH Lee, A Polley, JT Groves… - Molecular biology of …, 2015 - Am Soc Cell Biol
Molecular diffusion at the surface of living cells is believed to be predominantly driven by
thermal kicks. However, there is growing evidence that certain cell surface molecules are …

Membrane protein dynamics and functional implications in mammalian cells

FJ Alenghat, DE Golan - Current topics in membranes, 2013 - Elsevier
The organization of the plasma membrane is both highly complex and highly dynamic. One
manifestation of this dynamic complexity is the lateral mobility of proteins within the plane of …

Investigation of nano-and microdomains formed by ceramide 1 phosphate in lipid bilayers

D Drabik, M Drab, S Penič, A Iglič, A Czogalla - Scientific reports, 2023 - nature.com
Biological membranes are renowned for their intricate complexity, with the formation of
membrane domains being pivotal to the successful execution of numerous cellular …

Ultrafast diffusion of a fluorescent cholesterol analog in compartmentalized plasma membranes

N Hiramoto‐Yamaki, KAK Tanaka, KGN Suzuki… - Traffic, 2014 - Wiley Online Library
Cholesterol distribution and dynamics in the plasma membrane (PM) are poorly understood.
The recent development of Bodipy488‐conjugated cholesterol molecule (Bdp‐Chol) …

Imaging fluorescence fluctuation spectroscopy: new tools for quantitative bioimaging

N Bag, T Wohland - Annual review of physical chemistry, 2014 - annualreviews.org
Fluorescence fluctuation spectroscopy (FFS) techniques provide information at the single-
molecule level with excellent time resolution. Usually applied at a single spot in a sample …

[HTML][HTML] Surfactin cyclic lipopeptides change the plasma membrane composition and lateral organization in mammalian cells

K Wojtowicz, A Czogalla, T Trombik… - Biochimica et Biophysica …, 2021 - Elsevier
The specific structure and composition of the cell plasma membrane (PM) is crucial for many
cellular processes and can be targeted by various substances with potential medical …