Clinical islet transplantation has progressed considerably over the past 12 years, and> 750
patients with type 1 diabetes have received islet transplants internationally over this time …

Remarkable progress has been made in islet transplantation over a span of 40 years. Once
just an experimental curiosity in mice, this therapy has moved forward, and can now provide …

The Collaborative Islet Transplant Registry (CITR) collects data on clinical islet isolations
and transplants. This retrospective report analyzed 1017 islet isolation procedures …

Uncontrolled glycemia is a hallmark of diabetes mellitus and promotes morbidities like
neuropathy, nephropathy, and retinopathy. With the increasing prevalence of diabetes, both …

Tissue dissociation enzymes are critical reagents that affect the yield and quality of human
pancreatic islets required for islet transplantation. The United States Food and Drug …

The reproducible isolation and accurate characterization of thymic epithelial cell (TEC)
subsets is of critical importance to the ongoing study of thymopoiesis and its functional …

Type 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high
morbidity and mortality rates in young adults of productive age. Intensive insulin therapy has …

Type 1 diabetes (T1D) has been determined to be an autoimmune disease involving the
selective destruction of insulin-producing β-cells in the pancreatic islets of Langerhans that …

Background Autotransplantation of cryopreserved ovarian cortex can be associated with a
risk of cancer cell reseeding. This issue could be eliminated by grafting isolated preantral …

Background We evaluated 3 commercially available enzymes for pancreatic digestion by
comparing key parameters during the islet isolation process, as well as islet quality after …