Bioinformatics has been playing a crucial role in the scientific progress to fight against the
pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe acute …

Heparin-binding protein (HBP) is a cationic antibacterial protein derived from multinuclear
neutrophils and an important biomarker of infectious diseases. The correct identification of …

Abstract The 2022 Nucleic Acids Research Database Issue contains 185 papers, including
87 papers reporting on new databases and 85 updates from resources previously published …

Modeling-based anti-cancer drug sensitivity prediction has been extensively studied in
recent years. While most drug sensitivity prediction models only use gene expression data …

Abstract Characterization of the specific expression and chromatin profiles of genes enables
understanding how they contribute to tissue/organ development and the mechanisms …

The impact of the ravages of COVID-19 on people's lives is obvious, and the development of
novel potential inhibitors against SARS-CoV-2 main protease (Mpro), which has been …

The ongoing pandemic of the coronavirus disease 2019 (COVID-19) caused by the severe
acute respiratory syndrome coronavirus 2 still has limited treatment options. Our …

Viral infections can modulate the widespread alternations of cellular splicing, favouring viral
replication within the host cells by overcoming host immune responses. However, how …

Secondary infections contribute significantly to covid-19 mortality but driving factors remain
poorly understood. Autopsies of 20 covid-19 cases and 14 controls from the first pandemic …

Tumor metastasis is the main cause of death in cancer patients. Early prediction of tumor
metastasis can allow for timely intervention. At present, research on tumor metastasis mainly …