The manipulation of apoptosis for cancer therapy using BH3-mimetic drugs
ST Diepstraten, MA Anderson, PE Czabotar… - Nature Reviews …, 2022 - nature.com
Apoptosis is a form of programmed cell death that is regulated by the balance between
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …
prosurvival and proapoptotic BCL-2 protein family members. Evasion of apoptosis is a …
The World Health Organization (WHO) classification of the myeloid neoplasms
JW Vardiman, NL Harris… - Blood, The Journal of the …, 2002 - ashpublications.org
A World Health Organization (WHO) classification of hematopoietic and lymphoid
neoplasms has recently been published. This classification was developed through the …
neoplasms has recently been published. This classification was developed through the …
Clinical experience with the BCL 2‐inhibitor venetoclax in combination therapy for relapsed and refractory acute myeloid leukemia and related myeloid malignancies
CD DiNardo, CR Rausch, C Benton… - American journal of …, 2018 - Wiley Online Library
Introduction Venetoclax (VEN), a selective BCL2 inhibitor, has single‐agent activity in
relapsed and refractory (R/R) acute myeloid leukemia (AML), and efficacy in lower intensity …
relapsed and refractory (R/R) acute myeloid leukemia (AML), and efficacy in lower intensity …
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype
AA Basiorka, KL McGraw, EA Eksioglu… - Blood, The Journal …, 2016 - ashpublications.org
Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …
cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is …
Venetoclax and hypomethylating agents (HMAs) induce high response rates in MDS, including patients after HMA therapy failure
BJ Ball, CA Famulare, EM Stein, MS Tallman… - Blood …, 2020 - ashpublications.org
Key Points Treatment-naive and relapsed/refractory MDS patients receiving venetoclax and
HMAs have an ORR of 59% with 63% of responders proceeding to transplant. Allogeneic …
HMAs have an ORR of 59% with 63% of responders proceeding to transplant. Allogeneic …
Myelodysplastic syndromes
A Tefferi, JW Vardiman - New England Journal of Medicine, 2009 - Mass Medical Soc
This review gives an account of the clinical and hematologic features of the myelodysplastic
syndromes. It supplies the latest classification of these disorders, discusses the cytogenetic …
syndromes. It supplies the latest classification of these disorders, discusses the cytogenetic …
How cell death shapes cancer
V Labi, M Erlacher - Cell death & disease, 2015 - nature.com
Apoptosis has been established as a mechanism of anti-cancer defense. Members of the
BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found …
BCL-2 family are critical mediators of apoptotic cell death in health and disease, often found …
Myelodysplastic syndromes
L Adès, R Itzykson, P Fenaux - The Lancet, 2014 - thelancet.com
Myelodysplastic syndromes are clonal marrow stem-cell disorders, characterised by
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …
ineffective haemopoiesis leading to blood cytopenias, and by progression to acute myeloid …
Genetics of progression from MDS to secondary leukemia
AJ Menssen, MJ Walter - Blood, The Journal of the American …, 2020 - ashpublications.org
Our understanding of the genetics of acute myeloid leukemia (AML) development from
myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation …
myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation …
The rise of apoptosis: targeting apoptosis in hematologic malignancies
R Valentin, S Grabow, MS Davids - Blood, The Journal of the …, 2018 - ashpublications.org
Dysregulation of the B-cell leukemia/lymphoma-2 (BCL-2) family of proteins of the intrinsic
apoptotic pathway is fundamental to the pathophysiology of many hematologic …
apoptotic pathway is fundamental to the pathophysiology of many hematologic …