Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

Neurodegenerative diseases are a group of pathological conditions that cause motor inc-
ordination (jerking movements), cognitive and memory impairments result from …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Summary Inhibition of sirtuin 2 (SIRT2) deacetylase mediates protective effects in cell and
invertebrate models of Parkinson's disease and Huntington's disease (HD). Here we report …

Modulation of gene expression is a constant and necessary event for mammalian brain
function. An important way of regulating gene expression is through the remodeling of …

Alzheimer's disease (AD) is a mostly sporadic brain disorder characterized by cognitive
decline resulting from selective neurodegeneration in the hippocampus and cerebral cortex …

The known genetic cause of Huntington's disease (HD) has fueled considerable progress in
understanding its pathobiology and the development of therapeutic approaches aimed at …

Objective To investigate whether a histone deacetylase inhibitor (HDACi) would be effective
in an in vitro model for the neurodegenerative disease Friedreich ataxia (FRDA) and to …

Neuropsychiatric pathologies, including neurodegenerative diseases and
neurodevelopmental syndromes, are frequently associated with dysregulation of various …

Acetylation is a key post-translational modification (PTM) involved in the regulation of both
histone and non-histone proteins. It controls cellular processes such as DNA transcription …