The interplay of mathematical modelling with experiments is one of the central elements in
systems biology. The aim of reverse engineering is to infer, analyse and understand …

Metabolic networks are regulated to ensure the dynamic adaptation of biochemical reaction
fluxes to maintain cell homeostasis and optimal metabolic fitness in response to …

The valorization of volatile fatty acids into microbial lipids by the oleaginous yeast Yarrowia
lipolytica was investigated. Therefore, a two-stage fed-batch strategy was designed: the …

Maximizing the production of a desired small molecule is one of the primary goals in
metabolic engineering. Recent advances in the nascent field of synthetic biology have …

In the era of sustainable development, the use of cell factories to produce various
compounds by fermentation has attracted extensive attention; however, industrial …

Pentose sugars are widespread in nature and two of them, D-xylose and L-arabinose
belong to the most abundant sugars being the second and third by abundance sugars in dry …

Since centuries vegetable oils are consumed as human food but it also finds applications in
biodiesel production which is attracting more attention. But due to being in competition with …

Highlights•Dynamic flux models are useful for design, control, and optimization of
bioprocesses.•Dynamic metabolic flux analysis (DMFA) estimates transient in vivo …

Proteins secreted by Gram-positive bacteria are released into the culture medium with the
obvious benefit that they usually retain their native conformation. This property makes these …

Flux balance analysis (FBA) is currently one of the most important and used techniques for
estimation of metabolic reaction rates (fluxes). This mathematical approach utilizes an …